Reactome | FOXO-mediated transcription of cell cycle genes

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FOXO-mediated transcription of cell cycle genes Show undefined attributes

authored	[InstanceEdit:9624371] Orlic-Milacic, Marija, 2018-10-11
created	[InstanceEdit:9617827] Orlic-Milacic, Marija, 2018-08-30
crossReference	[DatabaseIdentifier:12325582] BioModels Database:BIOMD0000000582
dbId	9617828
displayName	FOXO-mediated transcription of cell cycle genes
edited	[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
eventOf	[Pathway:R-HSA-9614085] FOXO-mediated transcription - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9617840] FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter - Homo sapiens [Reaction:R-HSA-9617996] FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 - Homo sapiens [Reaction:R-HSA-9618004] FOXO:SMAD complex binds CDKN1A gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9617838] CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 - Homo sapiens [Reaction:R-HSA-9618021] FOXG1 binds FOXO:SMAD complexes - Homo sapiens [Reaction:R-HSA-6803403] PCBP4 binds the CDKN1A mRNA - Homo sapiens [BlackBoxEvent:R-HSA-6803411] PCBP4 modulates CDKN1A translation - Homo sapiens [BlackBoxEvent:R-HSA-9617848] CDKN1B gene expression is stimulated by FOXO1,FOXO3,FOXO4 - Homo sapiens [Reaction:R-HSA-9617852] FOXO3,FOXO4,(FOXO1) bind GADD45A gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9617853] GADD45A gene expression is stimulated by FOXO3,FOXO4,(FOXO1) - Homo sapiens [Reaction:R-HSA-9620788] FOXO1,FOXO3,FOXO4 binds RBL2 gene - Homo sapiens [BlackBoxEvent:R-HSA-9620813] RBL2 gene expression is stimulated by FOXO1,FOXO3,FOXO4 - Homo sapiens [Reaction:R-HSA-9620828] FOXO1,FOXO3,(FOXO4) binds CCNG2 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9620837] CCNG2 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) - Homo sapiens [Reaction:R-HSA-9620891] FOXO3 binds BTG1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9620915] BTG1 gene expression is stimulated by FOXO3 - Homo sapiens [Reaction:R-HSA-9624976] FOXO1,FOXO3 binds CAV1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9624985] CAV1 gene expression is stimulated by FOXO1,FOXO3 - Homo sapiens [Reaction:R-HSA-9625406] FOXO1,FOXO3 bind KLF4 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9625409] KLF4 gene expression is stimulated by FOXO1,FOXO3 - Homo sapiens [Reaction:R-HSA-9625510] FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9625520] MSTN gene expression is stimulated by FOXO1 and p-2S-SMAD2/3:SMAD4 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9620894] Differential regulation of Foxo3a target genes in erythropoiesis [LiteratureReference:9620921] FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1 [LiteratureReference:9620798] FOXO transcription factors cooperate with delta EF1 to activate growth suppressive genes in B lymphocytes [LiteratureReference:9620843] Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead [LiteratureReference:9618273] AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 [LiteratureReference:9620784] Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors [LiteratureReference:9617884] DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein [LiteratureReference:9617875] FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress [LiteratureReference:9617888] FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide [LiteratureReference:9617886] FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress [LiteratureReference:9617872] FOXO1-dependent DNA damage repair is regulated by JNK in lung cancer cells [LiteratureReference:9618307] Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1) [LiteratureReference:9620538] Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells [LiteratureReference:9617983] Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation [LiteratureReference:9617991] Forkhead box O1 (FOXO1) protein, but not p53, contributes to robust induction of p21 expression in fasted mice [LiteratureReference:9624978] Direct control of caveolin-1 expression by FOXO transcription factors [LiteratureReference:9624995] FoxO3a (Forkhead Box O3a) deficiency protects Idiopathic Pulmonary Fibrosis (IPF) fibroblasts from type I polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and Fas [LiteratureReference:9625007] The estrogen receptor ? is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness [LiteratureReference:9625019] Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc [LiteratureReference:9625407] KLF4 is a FOXO target gene that suppresses B cell proliferation [LiteratureReference:9625491] Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors [LiteratureReference:9620916] Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	FOXO-mediated transcription of cell cycle genes
orthologousEvent	[Pathway:R-CEL-9617828] FOXO-mediated transcription of cell cycle genes - Caenorhabditis elegans [Pathway:R-DME-9617828] FOXO-mediated transcription of cell cycle genes - Drosophila melanogaster [Pathway:R-GGA-9617828] FOXO-mediated transcription of cell cycle genes - Gallus gallus [Pathway:R-DRE-9617828] FOXO-mediated transcription of cell cycle genes - Danio rerio [Pathway:R-SSC-9617828] FOXO-mediated transcription of cell cycle genes - Sus scrofa [Pathway:R-BTA-9617828] FOXO-mediated transcription of cell cycle genes - Bos taurus [Pathway:R-MMU-9617828] FOXO-mediated transcription of cell cycle genes - Mus musculus [Pathway:R-RNO-9617828] FOXO-mediated transcription of cell cycle genes - Rattus norvegicus [Pathway:R-CFA-9617828] FOXO-mediated transcription of cell cycle genes - Canis familiaris
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9617828
summation	[Summation:9624166] FOXO transcription factors induce expression of several gene...

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[Pathway:R-HSA-9614085] FOXO-mediated transcription

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