PCBP4 modulates CDKN1A translation

Stable Identifier
R-HSA-6803411
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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PCBP4 modulates CDKN1A translation
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PCBP4 binding to the 3'-UTR of the CDKN1A (p21) mRNA reduces half-life of the CDKN1A mRNA and the amount of CDKN1A protein. Upon DNA damage, TP53-mediated induction of CDKN1A is rapid, while the induction of PCBP4 is more gradual. It is hypothesized that, under prolonged stress, PCBP4-mediated down-regulation of CDKN1A may switch from G1 cell cycle arrest to G2 arrest, which may precede apoptosis (Scoumanne et al. 2011).
Literature References
PubMed ID Title Journal Year
20817677 The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability

Chen, X, Cho, SJ, Scoumanne, A, Zhang, J

Nucleic Acids Res. 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PCBP4:CDKN1A mRNA [cytosol] (Homo sapiens)
Active Unit
PCBP4 [cytosol]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Bertaggia, E  (2018-10-26)
Zaccara, S  (2016-02-04)
Donlon, T  (2018-10-17)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-07)
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