Reactome | PCBP4 binds the CDKN1A mRNA

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PCBP4 binds the CDKN1A mRNA Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6803407] Orlic-Milacic, Marija, 2015-10-06
dbId	6803403
displayName	PCBP4 binds the CDKN1A mRNA
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14 [InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
eventOf	[Pathway:R-HSA-69895] Transcriptional activation of cell cycle inhibitor p21 - Homo sapiens [Pathway:R-HSA-9617828] FOXO-mediated transcription of cell cycle genes - Homo sapiens [Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6803411] PCBP4 modulates CDKN1A translation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6803386] CDKN1A mRNA [cytosol] [EntityWithAccessionedSequence:R-HSA-6803382] PCBP4 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6803408] The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PCBP4 binds the CDKN1A mRNA
output	[Complex:R-HSA-6803405] PCBP4:CDKN1A mRNA [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-6803388] TP53 stimulates CDKN1A (p21) transcription - Homo sapiens [BlackBoxEvent:R-HSA-6803400] TP53 stimulates PCBP4 expression - Homo sapiens [BlackBoxEvent:R-HSA-9617838] CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6803403
summation	[Summation:6803410] PCBP4 binds the 3'-UTR of the CDKN1A (p21) mRNA and reduces ...

Referrals

(hasEvent)	[Pathway:R-HSA-9617828] FOXO-mediated transcription of cell cycle genes [Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest [Pathway:R-HSA-69895] Transcriptional activation of cell cycle inhibitor p21
(precedingEvent)	[BlackBoxEvent:R-HSA-6803411] PCBP4 modulates CDKN1A translation