Reactome | TP53 stimulates CDKN1A (p21) transcription

Schema > BlackBoxEvent > Entries

TP53 stimulates CDKN1A (p21) transcription Show undefined attributes

authored	[InstanceEdit:187964] Matthews, L, 2006-09-29 13:54:26 [InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:6803384] Orlic-Milacic, Marija, 2015-10-06
dbId	6803388
deleted	[Deleted:8871597] Deletion of instance: 188383
displayName	TP53 stimulates CDKN1A (p21) transcription
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest - Homo sapiens [Pathway:R-HSA-69895] Transcriptional activation of cell cycle inhibitor p21 - Homo sapiens
followingEvent	[Reaction:R-HSA-8852362] GTSE1 binds CDKN1A - Homo sapiens [Reaction:R-HSA-6803403] PCBP4 binds the CDKN1A mRNA - Homo sapiens [BlackBoxEvent:R-HSA-6803411] PCBP4 modulates CDKN1A translation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3786256] CDKN1A gene [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69405] WAF1, a potential mediator of p53 tumor suppression. [LiteratureReference:6803710] Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates CDKN1A (p21) transcription
output	[EntityWithAccessionedSequence:R-HSA-6803386] CDKN1A mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-6803801] TP53 in complex with ZNF385A binds the CDKN1A promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-6803387] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:ZNF385A:CDKN1A Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642151] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:ZNF385A:CDKN1A Gene [nucleoplasm]' Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188313] Coqueret, O, 2006-10-06 08:59:06 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
revised	[InstanceEdit:6803381] Orlic-Milacic, Marija, 2015-10-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6803388
summation	[Summation:6803383] Binding of TP53 (p53) to its response elements in the promot...

Referrals

(replacementInstances)	[Deleted:8871597] Deletion of instance: 188383
(precedingEvent)	[Reaction:R-HSA-8852362] GTSE1 binds CDKN1A [Reaction:R-HSA-6803403] PCBP4 binds the CDKN1A mRNA [BlackBoxEvent:R-HSA-6803411] PCBP4 modulates CDKN1A translation
(hasEvent)	[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest [Pathway:R-HSA-69895] Transcriptional activation of cell cycle inhibitor p21