TP53 stimulates CDKN1A (p21) transcription

Stable Identifier
R-HSA-6803388
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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TP53 stimulates CDKN1A (p21) transcription
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Binding of TP53 (p53) to its response elements in the promoter of the CDKN1A (p21) gene stimulates CDKN1A transcription (El-Deiry et al. 1993). Binding of ZNF385A (HZF) to the DNA binding domain of TP53 facilitates CDKN1A induction and the consequent cell cycle arrest (Das et al. 2007).
Literature References
PubMed ID Title Journal Year
8242752 WAF1, a potential mediator of p53 tumor suppression.

Tokino, T, el-Deiry, WS, Kinzler, KW, Vogelstein, B, Lin, D, Mercer, WE, Parsons, R, Trent, JM, Velculescu, VE, Levy, DB

Cell 1993
17719541 Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

Bernstein, A, Aaronson, SA, Kimura, Y, Raj, L, Lee, SW, Das, S, Zhao, B

Cell 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:ZNF385A:CDKN1A Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer:ZNF385A [nucleoplasm]
Authored
Matthews, L  (2006-09-29)
Orlic-Milacic, M  (2015-10-14)
Reviewed
Coqueret, O  (2006-10-06)
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-06)
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