Reactome | TP53 in complex with ZNF385A binds the CDKN1A promoter

Schema > Reaction > Entries

TP53 in complex with ZNF385A binds the CDKN1A promoter Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15 [InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6803800] Orlic-Milacic, Marija, 2015-10-07
dbId	6803801
displayName	TP53 in complex with ZNF385A binds the CDKN1A promoter
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest - Homo sapiens [Pathway:R-HSA-69895] Transcriptional activation of cell cycle inhibitor p21 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6803388] TP53 stimulates CDKN1A (p21) transcription - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3786256] CDKN1A gene [nucleoplasm] [Complex:R-HSA-6803718] p-S15,S20-TP53 Tetramer:ZNF385A [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69405] WAF1, a potential mediator of p53 tumor suppression. [LiteratureReference:6803710] Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation [LiteratureReference:8856089] p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 in complex with ZNF385A binds the CDKN1A promoter
output	[Complex:R-HSA-6803802] p-S15,S20-TP53 Tetramer:ZNF385A:CDKN1A Gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6803719] TP53 binds ZNF385A - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
revised	[InstanceEdit:6803794] Orlic-Milacic, Marija, 2015-10-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6803801
summation	[Summation:6804124] TP53 (p53) binds at least two p53 response elements in the p...

Referrals

(hasEvent)	[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest [Pathway:R-HSA-69895] Transcriptional activation of cell cycle inhibitor p21
(precedingEvent)	[BlackBoxEvent:R-HSA-6803388] TP53 stimulates CDKN1A (p21) transcription

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