Reactome | RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-6802669] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - Homo sapiens [Complex:R-HSA-6802667] mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-6802925] Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs - Homo sapiens
created	[InstanceEdit:6802619] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	6802617
disease	[Disease:1500689] cancer
displayName	RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane]
hasComponent	[DefinedSet:R-HSA-6802622] p-RAF/BRAF homo/heterodimer [plasma membrane] [Complex:R-HSA-6802607] RAS mutants:GTP [plasma membrane]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
maxDepth	5
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15
name	RAS mutants:GTP:p-RAF homo/heterodimer
producedByEvent	[Reaction:R-HSA-6802924] RAF is phosphorylated downstream of oncogenic RAS - Homo sapiens [Reaction:R-HSA-6803233] Dissociation of oncogenic RAS:RAF complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-6802617
updateTrackers	[UpdateTracker:9900791] Update Tracker - [Complex:6802617] RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] - v70:[updateContainedComponent]

(updatedInstance)	[UpdateTracker:9900791] Update Tracker - [Complex:6802617] RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] - v70:[updateContainedComponent]
(output)	[Reaction:R-HSA-6802924] RAF is phosphorylated downstream of oncogenic RAS [Reaction:R-HSA-6803233] Dissociation of oncogenic RAS:RAF complex
(input)	[Reaction:R-HSA-6802925] Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs
(diseaseEntity)	[EntityFunctionalStatus:6802867] gain_of_function of RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane]
(hasComponent)	[Complex:R-HSA-6802667] mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-6802669] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-6802672] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]