Reactome | RAF is phosphorylated downstream of moderate kinase activity BRAF mutants

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RAF is phosphorylated downstream of moderate kinase activity BRAF mutants Show undefined attributes

authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
catalystActivity	[CatalystActivity:5672970] protein serine/threonine/tyrosine kinase activity of RAF activating kinases [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6802917] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	6802916
disease	[Disease:1500689] cancer
displayName	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants
edited	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
entityFunctionalStatus	[EntityFunctionalStatus:6802872] gain_of_function of RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane]
eventOf	[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-6802639] RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:5672454] Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling [LiteratureReference:6790314] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling [LiteratureReference:6790420] Targeting RAS-ERK signalling in cancer: promises and challenges [LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants
normalReaction	[Reaction:R-HSA-5672969] Phosphorylation of RAF
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-6802642] RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane]
precedingEvent	[Reaction:R-HSA-6802915] Moderate kinase activity BRAF mutants bind RAS:GTP - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6802916
summation	[Summation:6802203] Homo- or heterodimerization (with RAF1, also known as CRAF) ...

Referrals

(hasEvent)	[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants
(precedingEvent)	[Reaction:R-HSA-6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs

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