Reactome | high kinase activity BRAF mutants [cytosol]

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high kinase activity BRAF mutants [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-6802578] BRAF inhibitors:high kinase activity BRAF mutants [cytosol] - Homo sapiens [Complex:R-HSA-6802664] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] - Homo sapiens [Complex:R-HSA-6802662] high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-6802938] Inhibitors bind and inhibit highly active BRAF mutants - Homo sapiens [Reaction:R-HSA-6802912] High kinase activity BRAF mutants bind MAP2Ks and MAPKs - Homo sapiens
created	[InstanceEdit:6802577] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020780] Mondo:0015280
dbId	6802579
disease	[Disease:1500689] cancer [Disease:9651119] cardiofaciocutaneous syndrome
displayName	high kinase activity BRAF mutants [cytosol]
hasMember	[EntityWithAccessionedSequence:R-HSA-6802498] BRAF V600E [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6802381] BRAF G469A [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6802281] BRAF T599dup [cytosol] - Homo sapiens [Complex:R-HSA-6802656] V600E BRAF splice variant dimer [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648833] BRAF K601E [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9648857] BRAF K601N [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9651134] BRAF G534R [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9651147] BRAF L485F [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9651157] BRAF Q257R [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9651161] BRAF S467A [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9651142] BRAF K499E [cytosol] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:9650998] Biochemical characterization of novel germline BRAF and MEK mutations in cardio-facio-cutaneous syndrome
maxDepth	4
modified	[InstanceEdit:9651207] Rothfels, Karen, 2019-06-25
name	high kinase activity BRAF mutants
producedByEvent	[Reaction:R-HSA-6803227] Dissociation of high activity BRAF complexes - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-6802579
updateTrackers	[UpdateTracker:9900627] Update Tracker - [DefinedSet:6802579] high kinase activity BRAF mutants [cytosol] - v70:[addDisease, addHasMember, addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9900627] Update Tracker - [DefinedSet:6802579] high kinase activity BRAF mutants [cytosol] - v70:[addDisease, addHasMember, addLiteratureReference]
(hasComponent)	[Complex:R-HSA-6802578] BRAF inhibitors:high kinase activity BRAF mutants [cytosol] [Complex:R-HSA-6802666] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] [Complex:R-HSA-6802664] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] [Complex:R-HSA-6802662] high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol]
(input)	[Reaction:R-HSA-6802938] Inhibitors bind and inhibit highly active BRAF mutants [Reaction:R-HSA-6802912] High kinase activity BRAF mutants bind MAP2Ks and MAPKs
(output)	[Reaction:R-HSA-6803227] Dissociation of high activity BRAF complexes
(diseaseEntity)	[EntityFunctionalStatus:6802883] gain_of_function of high kinase activity BRAF mutants [cytosol]

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