Reactome | Inhibitors bind and inhibit highly active BRAF mutants

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Inhibitors bind and inhibit highly active BRAF mutants Show undefined attributes

authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6802939] Rothfels, Karen, 2015-10-02
dbId	6802938
disease	[Disease:1500689] cancer [Disease:9651119] cardiofaciocutaneous syndrome
displayName	Inhibitors bind and inhibit highly active BRAF mutants
edited	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
entityFunctionalStatus	[EntityFunctionalStatus:6802883] gain_of_function of high kinase activity BRAF mutants [cytosol]
eventOf	[Pathway:R-HSA-6802948] Signaling by high-kinase activity BRAF mutants - Homo sapiens
input	[CandidateSet:R-ALL-6802559] BRAF inhibitors [cytosol] [DefinedSet:R-HSA-6802579] high kinase activity BRAF mutants [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6790256] Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885 [LiteratureReference:6790292] Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Inhibitors bind and inhibit highly active BRAF mutants
output	[Complex:R-HSA-6802578] BRAF inhibitors:high kinase activity BRAF mutants [cytosol]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6802938
summation	[Summation:6802240] The class I ATP competitive inhibitors vemurafenib and dabra...

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[Pathway:R-HSA-6802948] Signaling by high-kinase activity BRAF mutants

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