Reactome | BRAF K601N [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9648853] Rothfels, Karen, 2019-06-07
crossReference	[DatabaseIdentifier:12021102] Mondo:0004977 [DatabaseIdentifier:9648855] COSMIC:COSV56058093
dbId	9648857
disease	[Disease:1500699] lung cancer [Disease:9648856] angioimmunoblastic T-cell lymphoma [Disease:1614289] melanoma
displayName	BRAF K601N [cytosol]
endCoordinate	766
hasModifiedResidue	[ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ReplacedResidue:9648854] L-lysine 601 replaced with L-asparagine
inDisease	true
literatureReference	[LiteratureReference:9648722] BRAF mutations in non-small cell lung cancer [LiteratureReference:9646931] Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients [LiteratureReference:6802011] Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas
maxDepth	1
memberOf	[DefinedSet:R-HSA-6802579] high kinase activity BRAF mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:9656557] Rothfels, Karen, 2019-08-02
name	BRAF K601N B-RAF
referenceEntity	[ReferenceGeneProduct:uniprot:P15056] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9648857
startCoordinate	2

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