Reactome | GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA

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GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA Show undefined attributes

authored	[InstanceEdit:6786891] May, Bruce, 2015-07-10
category	omitted
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6787465] May, Bruce, 2015-07-13
dbId	6787403
displayName	GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA
edited	[InstanceEdit:6786891] May, Bruce, 2015-07-10
eventOf	[Pathway:R-HSA-6787450] tRNA modification in the mitochondrion - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6787447] TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:436401] mitochondrial tRNA modification
inferredFrom	[BlackBoxEvent:R-SCE-6787377] MSS1 and MTO1 transform uridine-34 to 5-carboxymethylaminomethyluridine-34 in tRNA - Saccharomyces cerevisiae
input	[DefinedSet:R-HSA-6787446] tRNA(Leu,Lys) containing U-34 [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:6787419] MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention [LiteratureReference:6787376] MTO1 mutations are associated with hypertrophic cardiomyopathy and lactic acidosis and cause respiratory chain deficiency in humans and yeast [LiteratureReference:6787458] Mutations of the mitochondrial-tRNA modifier MTO1 cause hypertrophic cardiomyopathy and lactic acidosis [LiteratureReference:6787481] Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases [LiteratureReference:9676139] Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA
output	[DefinedSet:R-HSA-6787473] tRNA(Lys,Leu) containing 5-taurinomethylU-34 [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-6786881] TRNT1 polymerizes CCA at the 3' end of pre-tRNA - Homo sapiens
regulatedBy	[Requirement:9676141] Requirement by 'GTPBP3 [mitochondrial matrix]' [Requirement:9676134] Requirement by 'MTO1 [mitochondrial matrix]'
regulationReference	[RegulationReference:9676135] Requirement by 'MTO1 [mitochondrial matrix]' MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention [RegulationReference:9676132] Requirement by 'GTPBP3 [mitochondrial matrix]' Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24 [InstanceEdit:6808651] Powell, Christopher A, 2015-11-07
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6787403
summation	[Summation:6787513] A conserved pathway consisting of at least GTPBP3 (MSS1 in S...
updateTrackers	[UpdateTracker:9777389] Update Tracker - [BlackBoxEvent:6787403] GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA - v72:[addLiteratureReference, addRegulator, modifyText, removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9777389] Update Tracker - [BlackBoxEvent:6787403] GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA - v72:[addLiteratureReference, addRegulator, modifyText, removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-6787450] tRNA modification in the mitochondrion
(precedingEvent)	[BlackBoxEvent:R-HSA-6787447] TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA
(inferredTo)	[BlackBoxEvent:R-SCE-6787377] MSS1 and MTO1 transform uridine-34 to 5-carboxymethylaminomethyluridine-34 in tRNA