Reactome | tRNA modification in the mitochondrion

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tRNA modification in the mitochondrion Show undefined attributes

authored	[InstanceEdit:6786891] May, Bruce, 2015-07-10
created	[InstanceEdit:6787465] May, Bruce, 2015-07-13
dbId	6787450
displayName	tRNA modification in the mitochondrion
doi	10.3180/R-HSA-6787450.8
edited	[InstanceEdit:6786891] May, Bruce, 2015-07-10
eventOf	[Pathway:R-HSA-72306] tRNA processing - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:436401] mitochondrial tRNA modification
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-6787403] GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA - Homo sapiens [BlackBoxEvent:R-HSA-6787447] TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA - Homo sapiens [Reaction:R-HSA-6787525] TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58 - Homo sapiens [Reaction:R-HSA-6787566] PUS1 isoform 1 isomerizes uridine-27, uridine-28 to pseudouridine residues in tRNA(Lys,Ser) - Homo sapiens [Reaction:R-HSA-6787567] TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) - Homo sapiens [Reaction:R-HSA-6787594] TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 - Homo sapiens [Reaction:R-HSA-6787591] TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 - Homo sapiens [Reaction:R-HSA-9611218] YRDC synthesizes threonylcarbamoyladenylate - Homo sapiens [Reaction:R-HSA-9611197] OSGEPL1 threonylcarbamoylates adenosine-37 in tRNA - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-03-16
literatureReference	[LiteratureReference:6787401] tRNA biology in mitochondria [LiteratureReference:6787572] Role of tRNA modifications in human diseases [LiteratureReference:6785486] Post-transcriptional modifications to tRNA--a response to the genetic code degeneracy [LiteratureReference:6784542] Human mitochondrial tRNAs: biogenesis, function, structural aspects, and diseases
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	tRNA modification in the mitochondrion
orthologousEvent	[Pathway:R-CEL-6787450] tRNA modification in the mitochondrion - Caenorhabditis elegans [Pathway:R-DME-6787450] tRNA modification in the mitochondrion - Drosophila melanogaster [Pathway:R-GGA-6787450] tRNA modification in the mitochondrion - Gallus gallus [Pathway:R-XTR-6787450] tRNA modification in the mitochondrion - Xenopus tropicalis [Pathway:R-DRE-6787450] tRNA modification in the mitochondrion - Danio rerio [Pathway:R-SSC-6787450] tRNA modification in the mitochondrion - Sus scrofa [Pathway:R-BTA-6787450] tRNA modification in the mitochondrion - Bos taurus [Pathway:R-CFA-6787450] tRNA modification in the mitochondrion - Canis familiaris [Pathway:R-RNO-6787450] tRNA modification in the mitochondrion - Rattus norvegicus [Pathway:R-MMU-6787450] tRNA modification in the mitochondrion - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24 [InstanceEdit:6808651] Powell, Christopher A, 2015-11-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6787450
summation	[Summation:6787706] The 22 tRNAs encoded by the mitochondrial genome are modifie...
updateTrackers	[UpdateTracker:9777074] Update Tracker - [Pathway:6787450] tRNA modification in the mitochondrion - v72:[updateContainedRLE] [UpdateTracker:9953736] Update Tracker - [Pathway:6787450] tRNA modification in the mitochondrion - v93:[removeHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9777074] Update Tracker - [Pathway:6787450] tRNA modification in the mitochondrion - v72:[updateContainedRLE] [UpdateTracker:9953736] Update Tracker - [Pathway:6787450] tRNA modification in the mitochondrion - v93:[removeHasEvent]
(hasEvent)	[Pathway:R-HSA-72306] tRNA processing

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