Reactome | MSS1 and MTO1 transform uridine-34 to 5-carboxymethylaminomethyluridine-34 in tRNA

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MSS1 and MTO1 transform uridine-34 to 5-carboxymethylaminomethyluridine-34 in tRNA Show undefined attributes

authored	[InstanceEdit:6786891] May, Bruce, 2015-07-10
category	omitted
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6787465] May, Bruce, 2015-07-13
dbId	6787377
displayName	MSS1 and MTO1 transform uridine-34 to 5-carboxymethylaminomethyluridine-34 in tRNA
edited	[InstanceEdit:6786891] May, Bruce, 2015-07-10
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
input	[DefinedSet:R-SCE-6787440] tRNA(Gln,Glu,Lys) containing U-34 [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6787389] Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases [LiteratureReference:6787437] Combination of the loss of cmnm5U34 with the lack of s2U34 modifications of tRNALys, tRNAGlu, and tRNAGln altered mitochondrial biogenesis and respiration
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MSS1 and MTO1 transform uridine-34 to 5-carboxymethylaminomethyluridine-34 in tRNA
orthologousEvent	[BlackBoxEvent:R-HSA-6787403] GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA - Homo sapiens
output	[DefinedSet:R-SCE-6787406] tRNA(Gln,Glu,Lys) containing 5-carboxymethylaminomethylU-34 [mitochondrial matrix]
regulatedBy	[Requirement:9676143] Requirement by 'MSS1 [mitochondrial matrix]' [Requirement:9676133] Requirement by 'MTO1 [mitochondrial matrix]'
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24 [InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6808651] Powell, Christopher A, 2015-11-07 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25
schemaClass	BlackBoxEvent
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-6787377
summation	[Summation:6787515] A conserved pathway consisting of at least MSS1 and MTO1 mod...
updateTrackers	[UpdateTracker:9777179] Update Tracker - [BlackBoxEvent:6787377] MSS1 and MTO1 transform uridine-34 to 5-carboxymethylaminomethyluridine-34 in tRNA - v72:[addRegulator, removeCatalystActivity]

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(updatedInstance)

[UpdateTracker:9777179] Update Tracker - [BlackBoxEvent:6787377] MSS1 and MTO1 transform uridine-34 to 5-carboxymethylaminomethyluridine-34 in tRNA - v72:[addRegulator, removeCatalystActivity]

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