Reactome | TRNT1 polymerizes CCA at the 3' end of pre-tRNA

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TRNT1 polymerizes CCA at the 3' end of pre-tRNA Show undefined attributes

authored	[InstanceEdit:6786698] May, Bruce, 2015-07-09
catalystActivity	[CatalystActivity:6786869] 5'-3' RNA polymerase activity of TRNT1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:6786846] May, Bruce, 2015-07-10
dbId	6786881
displayName	TRNT1 polymerizes CCA at the 3' end of pre-tRNA
edited	[InstanceEdit:6786698] May, Bruce, 2015-07-09
eventOf	[Pathway:R-HSA-6785470] tRNA processing in the mitochondrion - Homo sapiens
followingEvent	[Reaction:R-HSA-6787594] TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 - Homo sapiens [Reaction:R-HSA-6787566] PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser) - Homo sapiens [Reaction:R-HSA-6787567] TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) - Homo sapiens [Reaction:R-HSA-6787525] TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58 - Homo sapiens [Reaction:R-HSA-6787591] TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 - Homo sapiens [BlackBoxEvent:R-HSA-6787403] GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:5083574] mitochondrial tRNA 3'-end processing
input	[DefinedSet:R-HSA-6786862] 5',3' cleaved pre-tRNA [mitochondrial matrix] [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-110577] CTP [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6786816] The 3' addition of CCA to mitochondrial tRNASer(AGY) is specifically impaired in patients with mutations in the tRNA nucleotidyl transferase TRNT1 [LiteratureReference:6786827] Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases [LiteratureReference:6786859] Decreased CCA-addition in human mitochondrial tRNAs bearing a pathogenic A4317G or A10044G mutation [LiteratureReference:6786814] Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD)
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRNT1 polymerizes CCA at the 3' end of pre-tRNA
output	[DefinedSet:R-HSA-6786887] Cleaved tRNA with 3' CCA [mitochondrial matrix] 3 × [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:R-HSA-6786854] Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24 [InstanceEdit:6808651] Powell, Christopher A, 2015-11-07 [InstanceEdit:6810571] Suzuki, Tsutomu, 2015-11-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6786881
summation	[Summation:6786841] TRNT1 (CCA-adding enzyme) polymerizes a nontemplated CCA seq...

Referrals

(precedingEvent)

[Reaction:R-HSA-6787594] TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9
[Reaction:R-HSA-6787566] PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser)
[Reaction:R-HSA-6787567] TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser)
[Reaction:R-HSA-6787525] TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58
[Reaction:R-HSA-6787591] TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9
[BlackBoxEvent:R-HSA-6787403] GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA

(hasEvent)

[Pathway:R-HSA-6785470] tRNA processing in the mitochondrion

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