Reactome | UVSSA:USP7 deubiquitinates ERCC6

Schema > Reaction > Entries

UVSSA:USP7 deubiquitinates ERCC6 Show undefined attributes

catalystActivity	[CatalystActivity:10065120] cysteine-type deubiquitinase activity of Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10065122
displayName	UVSSA:USP7 deubiquitinates ERCC6
eventOf	[Pathway:R-MMU-6781823] Formation of TC-NER Pre-Incision Complex - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Mus musculus
inferredFrom	[Reaction:R-HSA-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-MMU-6782063] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	UVSSA:USP7 deubiquitinates ERCC6
output	[Complex:R-MMU-6782066] TC-NER pre-incision complex [nucleoplasm] [DefinedSet:R-MMU-68524] Ub [nucleoplasm]
precedingEvent	[Reaction:R-MMU-6782004] Assembly of the pre-incision complex in TC-NER - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6782069
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6781823] Formation of TC-NER Pre-Incision Complex
(precedingEvent)	[Reaction:R-MMU-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER
(inferredTo)	[Reaction:R-HSA-6782069] UVSSA:USP7 deubiquitinates ERCC6