Reactome | Assembly of the pre-incision complex in TC-NER

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Assembly of the pre-incision complex in TC-NER Show undefined attributes

authored	[InstanceEdit:110274] Gopinathrao, G, 2004-01-29 18:08:32 [InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6781974] Orlic-Milacic, Marija, 2015-06-03
dbId	6782004
deleted	[Deleted:6793197] Deletion of instance: 109973
displayName	Assembly of the pre-incision complex in TC-NER
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16 [InstanceEdit:9862096] Orlic-Milacic, Marija, 2024-02-22
eventOf	[Pathway:R-HSA-6781823] Formation of TC-NER Pre-Incision Complex - Homo sapiens
followingEvent	[Reaction:R-HSA-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-65748] TCEA1 [nucleoplasm] [Complex:R-HSA-6781866] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] [Complex:R-HSA-6781845] UVSSA:USP7 [nucleoplasm] [Complex:R-HSA-6781957] XAB2 complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-67437] XPA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6781991] XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription [LiteratureReference:6781965] Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair [LiteratureReference:5689620] Nucleotide excision repair driven by the dissociation of CAK from TFIIH [LiteratureReference:6781971] Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair [LiteratureReference:6781993] UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair [LiteratureReference:6782030] KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR) [LiteratureReference:6781996] Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability [LiteratureReference:6782018] RNA interference against transcription elongation factor SII does not support its role in transcription-coupled nucleotide excision repair [LiteratureReference:6782011] Chromosomal protein HMGN1 enhances the rate of DNA repair in chromatin [LiteratureReference:6782015] Cockayne syndrome group B protein enhances elongation by RNA polymerase II [LiteratureReference:6781982] Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template [LiteratureReference:6782041] Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells [LiteratureReference:5689269] Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin [LiteratureReference:6782184] ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair [LiteratureReference:9862017] Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Assembly of the pre-incision complex in TC-NER
orthologousEvent	[Reaction:R-RNO-6782004] Assembly of the pre-incision complex in TC-NER - Rattus norvegicus [Reaction:R-CFA-6782004] Assembly of the pre-incision complex in TC-NER - Canis familiaris [Reaction:R-BTA-6782004] Assembly of the pre-incision complex in TC-NER - Bos taurus [Reaction:R-SSC-6782004] Assembly of the pre-incision complex in TC-NER - Sus scrofa [Reaction:R-XTR-6782004] Assembly of the pre-incision complex in TC-NER - Xenopus tropicalis [Reaction:R-GGA-6782004] Assembly of the pre-incision complex in TC-NER - Gallus gallus [Reaction:R-CEL-6782004] Assembly of the pre-incision complex in TC-NER - Caenorhabditis elegans [Reaction:R-MMU-6782004] Assembly of the pre-incision complex in TC-NER - Mus musculus
output	[Complex:R-HSA-6782063] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
revised	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6782004
summation	[Summation:6782051] In addition to ERCC6 (CSB) and the ERCC8 (CSA) ubiquitin lig...
updateTrackers	[UpdateTracker:9783314] Update Tracker - [Reaction:6782004] Assembly of the pre-incision complex in TC-NER - v57:[removeLiteratureReference] [UpdateTracker:9864300] Update Tracker - [Reaction:6782004] Assembly of the pre-incision complex in TC-NER - v88:[add_removeLiteratureReference, modifyText, removeInput]

Referrals

(precedingEvent)	[Reaction:R-HSA-6782069] UVSSA:USP7 deubiquitinates ERCC6
(hasEvent)	[Pathway:R-HSA-6781823] Formation of TC-NER Pre-Incision Complex
(replacementInstances)	[Deleted:6793197] Deletion of instance: 109973
(updatedInstance)	[UpdateTracker:9783314] Update Tracker - [Reaction:6782004] Assembly of the pre-incision complex in TC-NER - v57:[removeLiteratureReference] [UpdateTracker:9864300] Update Tracker - [Reaction:6782004] Assembly of the pre-incision complex in TC-NER - v88:[add_removeLiteratureReference, modifyText, removeInput]

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