Reactome | Recruitment of XPA and release of CAK

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Recruitment of XPA and release of CAK Show undefined attributes

authored	[InstanceEdit:73956] Joshi-Tope, G, 2003-07-14 15:01:00 [InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5689863] Orlic-Milacic, Marija, 2015-04-24
dbId	5689861
displayName	Recruitment of XPA and release of CAK
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
eventOf	[Pathway:R-HSA-5696395] Formation of Incision Complex in GG-NER - Homo sapiens
followingEvent	[Reaction:R-HSA-5696670] CHD1L is recruited to GG-NER site - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17148] nucleotide-excision repair, preincision complex assembly
input	[Complex:R-HSA-5689862] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-67437] XPA [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5689266] DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA [LiteratureReference:5689279] Physical and functional interaction between DDB and XPA in nucleotide excision repair [LiteratureReference:5689269] Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin [LiteratureReference:5689290] Damaged DNA-binding protein DDB stimulates the excision of cyclobutane pyrimidine dimers in vitro in concert with XPA and replication protein A [LiteratureReference:5689620] Nucleotide excision repair driven by the dissociation of CAK from TFIIH [LiteratureReference:5696648] Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Recruitment of XPA and release of CAK
orthologousEvent	[Reaction:R-MMU-5689861] Recruitment of XPA and release of CAK - Mus musculus [Reaction:R-SPO-5689861] Recruitment of XPA and release of CAK - Schizosaccharomyces pombe [Reaction:R-CEL-5689861] Recruitment of XPA and release of CAK - Caenorhabditis elegans [Reaction:R-DME-5689861] Recruitment of XPA and release of CAK - Drosophila melanogaster [Reaction:R-GGA-5689861] Recruitment of XPA and release of CAK - Gallus gallus [Reaction:R-XTR-5689861] Recruitment of XPA and release of CAK - Xenopus tropicalis [Reaction:R-SSC-5689861] Recruitment of XPA and release of CAK - Sus scrofa [Reaction:R-BTA-5689861] Recruitment of XPA and release of CAK - Bos taurus [Reaction:R-RNO-5689861] Recruitment of XPA and release of CAK - Rattus norvegicus
output	[Complex:R-HSA-69221] CAK [nucleoplasm] [Complex:R-HSA-5689300] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5691000] TFIIH binds GG-NER site to form a verification complex - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
revised	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5689861
summation	[Summation:5689860] XPA binds the DNA damage site through interaction with the T...

Referrals

(hasEvent)	[Pathway:R-HSA-5696395] Formation of Incision Complex in GG-NER
(precedingEvent)	[Reaction:R-HSA-5696670] CHD1L is recruited to GG-NER site

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