Reactome | DNA Double Strand Break Response

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DNA Double Strand Break Response Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328599
displayName	DNA Double Strand Break Response
eventOf	[Pathway:R-CFA-5693532] DNA Double-Strand Break Repair - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-CFA-5693571] Nonhomologous End-Joining (NHEJ) - Canis familiaris [Pathway:R-CFA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) - Canis familiaris
goBiologicalProcess	[GO_BiologicalProcess:9349] double-strand break repair
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-CFA-5693548] Sensing of DNA Double Strand Breaks - Canis familiaris [Pathway:R-CFA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Canis familiaris
inferredFrom	[Pathway:R-HSA-5693606] DNA Double Strand Break Response - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	DNA Double Strand Break Response
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-5693606
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-CFA-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-CFA-69620] Cell Cycle Checkpoints [Pathway:R-CFA-8878171] Transcriptional regulation by RUNX1 [Pathway:R-CFA-6806003] Regulation of TP53 Expression and Degradation [Pathway:R-CFA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) [Pathway:R-CFA-5693571] Nonhomologous End-Joining (NHEJ) [Pathway:R-CFA-5685939] HDR through MMEJ (alt-NHEJ)
(hasEvent)	[Pathway:R-CFA-5693532] DNA Double-Strand Break Repair
(precedingEvent)	[Pathway:R-CFA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) [Pathway:R-CFA-5693571] Nonhomologous End-Joining (NHEJ)
(inferredTo)	[Pathway:R-HSA-5693606] DNA Double Strand Break Response