Reactome | HDR through MMEJ (alt-NHEJ)

Schema > Pathway > Entries

HDR through MMEJ (alt-NHEJ) Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
created	[InstanceEdit:5685937] Orlic-Milacic, Marija, 2015-03-30
dbId	5685939
displayName	HDR through MMEJ (alt-NHEJ)
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693538] Homology Directed Repair - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5687465] MRN complex binds RBBP8 - Homo sapiens [Reaction:R-HSA-5687464] MRN and RBBP8 resect DNA DSBs in MMEJ - Homo sapiens [Reaction:R-HSA-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site - Homo sapiens [Reaction:R-HSA-5687640] POLQ extends annealed 3'-ssDNA overhangs in MMEJ - Homo sapiens [Reaction:R-HSA-5687653] PARP1,PARP2 dimers bound to MMEJ sites autoPARylate - Homo sapiens [Reaction:R-HSA-5687664] FEN1 cleaves displaced ssDNA flaps during MMEJ - Homo sapiens [Reaction:R-HSA-5687673] MRN recruits LIG3:XRCC1 to MMEJ sites - Homo sapiens [Reaction:R-HSA-5687675] LIG3 ligates remaining SSBs in MMEJ - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:5684117] CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle [LiteratureReference:5687512] Modulation of DNA end joining by nuclear proteins [LiteratureReference:5687636] The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies [LiteratureReference:5687506] Mammalian polymerase ? promotes alternative NHEJ and suppresses recombination [LiteratureReference:5687510] Homologous-recombination-deficient tumours are dependent on Pol?-mediated repair [LiteratureReference:5687496] Homology and enzymatic requirements of microhomology-dependent alternative end joining [LiteratureReference:5687501] Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase ? [LiteratureReference:5687678] Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway [LiteratureReference:5687690] Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining
maxDepth	2
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	HDR through MMEJ (alt-NHEJ)
orthologousEvent	[Pathway:R-MMU-5685939] HDR through MMEJ (alt-NHEJ) - Mus musculus [Pathway:R-SPO-5685939] HDR through MMEJ (alt-NHEJ) - Schizosaccharomyces pombe [Pathway:R-CEL-5685939] HDR through MMEJ (alt-NHEJ) - Caenorhabditis elegans [Pathway:R-DME-5685939] HDR through MMEJ (alt-NHEJ) - Drosophila melanogaster [Pathway:R-GGA-5685939] HDR through MMEJ (alt-NHEJ) - Gallus gallus [Pathway:R-XTR-5685939] HDR through MMEJ (alt-NHEJ) - Xenopus tropicalis [Pathway:R-DRE-5685939] HDR through MMEJ (alt-NHEJ) - Danio rerio [Pathway:R-SSC-5685939] HDR through MMEJ (alt-NHEJ) - Sus scrofa [Pathway:R-BTA-5685939] HDR through MMEJ (alt-NHEJ) - Bos taurus [Pathway:R-CFA-5685939] HDR through MMEJ (alt-NHEJ) - Canis familiaris [Pathway:R-RNO-5685939] HDR through MMEJ (alt-NHEJ) - Rattus norvegicus
precedingEvent	[BlackBoxEvent:R-HSA-5685953] SIRT6 deacetylates RBBP8 - Homo sapiens [Reaction:R-HSA-3785768] MRN complex binds DNA double strand breaks - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5685939
summation	[Summation:5687789] Homology directed repair (HDR) through microhomology-mediate...
updateTrackers	[UpdateTracker:9775257] Update Tracker - [Pathway:5685939] HDR through MMEJ (alt-NHEJ) - v80:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9775257] Update Tracker - [Pathway:5685939] HDR through MMEJ (alt-NHEJ) - v80:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-5693538] Homology Directed Repair
(hasEncapsulatedEvent)	[Pathway:R-HSA-5693606] DNA Double Strand Break Response

Cite Us!