ATM phosphorylates BRCA1 at serine residues S1387, S1423, S1...
| created | [InstanceEdit:83535] Matthews, L, 2003-11-18 00:00:00 |
| dbId | 83580 |
| displayName | ATM phosphorylates BRCA1 at serine residues S1387, S1423, S1... |
| literatureReference | |
| modified | [InstanceEdit:9824871] Orlic-Milacic, Marija, 2023-01-23 |
| schemaClass | Summation |
| text | ATM phosphorylates BRCA1 at serine residues S1387, S1423, S1457, and S1524 (Cortez et al. 1999, Gatei et al. 2000). At least a fraction of these sites and some additional BRCA1 SQ/TQ sites can also be phosphorylated by ATR (Tibbetts et al. 2000). ATM also phosphorylates BARD1, the heterodimerization partner of BRCA1, at threonine residues T714 and T734 (Kim et al. 2006). |
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