Reactome | Phosphorylation of BRCA1

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Phosphorylation of BRCA1 Show undefined attributes

authored	[InstanceEdit:209713] Saxena, A, 2008-01-04 18:30:50
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:265962] Saxena, A, 2008-04-21 13:32:36
dbId	265987
displayName	Phosphorylation of BRCA1
edited	[InstanceEdit:418967] D'Eustachio, P, 2009-04-27 17:09:41
eventOf	[Pathway:R-GGA-351433] ATM mediated phosphorylation of repair proteins - Gallus gallus
followingEvent	[Reaction:R-GGA-265968] Association of RAD51 with BRCA1 - Gallus gallus
inferredFrom	[Reaction:R-HSA-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-265944] BRCA1 [nucleoplasm]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:75196] Homologous recombinational repair of DNA ensures mammalian chromosome stability [LiteratureReference:351408] Nine novel conserved motifs in BRCA1 identified by the chicken orthologue [LiteratureReference:265963] Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells [LiteratureReference:351415] The absence of a functional relationship between ATM and BLM, the components of BASC, in DT40 cells [LiteratureReference:265881] Brca1 in immunoglobulin gene conversion and somatic hypermutation
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of BRCA1
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-265877] phosphorylated BRCA1 at S1189 and S1542 [nucleoplasm]
releaseDate	2009-06-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:418616] Borowiec, JA, 2009-04-23 20:19:22
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-265987
summation	[Summation:265930] BRCA1 phosphorylation occurs at multiple sites by ATM and is...

Referrals

(precedingEvent)	[Reaction:R-GGA-265968] Association of RAD51 with BRCA1
(hasEvent)	[Pathway:R-GGA-351433] ATM mediated phosphorylation of repair proteins
(inferredTo)	[Reaction:R-HSA-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM