Reactome | MAPK1/MAPK3 signaling

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MAPK1/MAPK3 signaling Show undefined attributes

authored	[InstanceEdit:5683031] Rothfels, Karen, 2015-03-11
created	[InstanceEdit:5684995] Rothfels, Karen, 2015-03-24
dbId	5684996
displayName	MAPK1/MAPK3 signaling
eventOf	[Pathway:R-HSA-5683057] MAPK family signaling cascades - Homo sapiens
figure	[Figure:9628954] /figures/ehld/R-HSA-5684996.svg
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade - Homo sapiens [Pathway:R-HSA-112409] RAF-independent MAPK1/3 activation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-06-17
literatureReference	[LiteratureReference:5673943] ERK1/2 MAP kinases: structure, function, and regulation [LiteratureReference:208231] Integrating signals from RTKs to ERK/MAPK [LiteratureReference:5684990] Differential regulation and properties of MAPKs [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:1497944] The RAF proteins take centre stage [LiteratureReference:5684236] Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway [LiteratureReference:5684220] A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1 [LiteratureReference:5684207] Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling [LiteratureReference:500549] The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions [LiteratureReference:8979640] NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells
maxDepth	5
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	MAPK1/MAPK3 signaling ERK1/ERK2 pathway
orthologousEvent	[Pathway:R-PFA-5684996] MAPK1/MAPK3 signaling - Plasmodium falciparum [Pathway:R-SCE-5684996] MAPK1/MAPK3 signaling - Saccharomyces cerevisiae [Pathway:R-SPO-5684996] MAPK1/MAPK3 signaling - Schizosaccharomyces pombe [Pathway:R-DDI-5684996] MAPK1/MAPK3 signaling - Dictyostelium discoideum [Pathway:R-MMU-5684996] MAPK1/MAPK3 signaling - Mus musculus [Pathway:R-DRE-5684996] MAPK1/MAPK3 signaling - Danio rerio [Pathway:R-GGA-5684996] MAPK1/MAPK3 signaling - Gallus gallus [Pathway:R-XTR-5684996] MAPK1/MAPK3 signaling - Xenopus tropicalis [Pathway:R-CEL-5684996] MAPK1/MAPK3 signaling - Caenorhabditis elegans [Pathway:R-DME-5684996] MAPK1/MAPK3 signaling - Drosophila melanogaster [Pathway:R-BTA-5684996] MAPK1/MAPK3 signaling - Bos taurus [Pathway:R-CFA-5684996] MAPK1/MAPK3 signaling - Canis familiaris [Pathway:R-RNO-5684996] MAPK1/MAPK3 signaling - Rattus norvegicus [Pathway:R-SSC-5684996] MAPK1/MAPK3 signaling - Sus scrofa
precedingEvent	[BlackBoxEvent:R-HSA-448728] IL19 binds IL20RA:JAK1:IL20RB - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5684996
summation	[Summation:5684987] The extracellular signal regulated kinases (ERKs) 1 and 2, a...
updateTrackers	[UpdateTracker:9783671] Update Tracker - [Pathway:5684996] MAPK1/MAPK3 signaling - v56:[updateContainedPathway] [UpdateTracker:9781644] Update Tracker - [Pathway:5684996] MAPK1/MAPK3 signaling - v60:[addLiteratureReference, modifyText] [UpdateTracker:9776937] Update Tracker - [Pathway:5684996] MAPK1/MAPK3 signaling - v73:[updateContainedPathway]

Referrals

(updatedInstance)	[UpdateTracker:9783671] Update Tracker - [Pathway:5684996] MAPK1/MAPK3 signaling - v56:[updateContainedPathway] [UpdateTracker:9781644] Update Tracker - [Pathway:5684996] MAPK1/MAPK3 signaling - v60:[addLiteratureReference, modifyText] [UpdateTracker:9776937] Update Tracker - [Pathway:5684996] MAPK1/MAPK3 signaling - v73:[updateContainedPathway]
(hasEvent)	[Pathway:R-HSA-5683057] MAPK family signaling cascades
(hasEncapsulatedEvent)	[Pathway:R-HSA-448424] Interleukin-17 signaling [Pathway:R-HSA-9764265] Regulation of CDH1 Expression and Function

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