Reactome | MAPK1/MAPK3 signaling

MAPK1/MAPK3 signaling

Stable Identifier

R-HSA-5684996

Type

Pathway

Species

Homo sapiens

Synonyms

ERK1/ERK2 pathway

ReviewStatus

5/5

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The extracellular signal regulated kinases (ERKs) 1 and 2, also known as MAPK3 and MAPK1, are phosphorylated by the MAP2Ks 1 and 2 in response to a wide range of extracellular stimuli to promote differentiation, proliferation, cell motility, cell survivial, metabolism and transcription, among others (reviewed in Roskoski, 2012b; McKay and Morrison, 2007; Raman et al, 2007). In the classical pathway, MAPK1/3 activation is triggered by the GEF-mediated activation of RAS at the plasma membrane, leading to the activation of the RAF MAP3Ks (reviewed in McKay and Morrison, 2007; Matallanas et al, 2011; Wellbrock et al, 2004). However, many physiological and pathological stimuli have been found to activate MAPK1/3 independently of RAF and RAS, acting instead through MAP3Ks such as MOS, TPL2 and AMPK (Dawson et al, 2008; Wang et al, 2009; Kuriakose et al, 2014; Awane et al, 1999). Activated MAPK1/3 phosphorylate numerous targets in both the nucleus and cytoplasm (reviewed in Yoon and Seger, 2006; Roskoski 2012b).

Literature References

PubMed ID	Title	Journal	Year
15520807	The RAF proteins take centre stage Wellbrock, C, Karasarides, M, Marais, R	Nat Rev Mol Cell Biol	2004
19520853	A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1 Wang, J, Whiteman, MW, Lian, H, Wang, G, Singh, A, Huang, D, Denmark, T	J. Biol. Chem.	2009
18199641	Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway Dawson, CW, Laverick, L, Morris, MA, Tramoutanis, G, Young, LS	J. Virol.	2008
25378393	Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling Kuriakose, T, Rada, B, Watford, WT	J. Biol. Chem.	2014
17496909	Differential regulation and properties of MAPKs Raman, M, Chen, W, Cobb, MH	Oncogene	2007
17496910	Integrating signals from RTKs to ERK/MAPK McKay, MM, Morrison, DK	Oncogene	2007
16393692	The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions Yoon, S, Seger, R	Growth Factors	2006
10228009	NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells Awane, M, Andres, PG, Li, DJ, Reinecker, HC	J. Immunol.	1999
22569528	ERK1/2 MAP kinases: structure, function, and regulation Roskoski, R Jr	Pharmacol. Res.	2012
21779496	Raf family kinases: old dogs have learned new tricks Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W	Genes Cancer	2011