Reactome | Regulation of CDH1 Expression and Function

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Regulation of CDH1 Expression and Function Show undefined attributes

authored	[InstanceEdit:9764267] Orlic-Milacic, Marija, 2022-02-10
created	[InstanceEdit:9764267] Orlic-Milacic, Marija, 2022-02-10
dbId	9764265
displayName	Regulation of CDH1 Expression and Function
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
eventOf	[Pathway:R-HSA-9764274] Regulation of Expression and Function of Type I Classical Cadherins - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9764560] Regulation of CDH1 Gene Transcription - Homo sapiens [Pathway:R-HSA-9764562] Regulation of CDH1 mRNA translation by microRNAs - Homo sapiens [Pathway:R-HSA-9768727] Regulation of CDH1 posttranslational processing and trafficking to plasma membrane - Homo sapiens [Pathway:R-HSA-9764561] Regulation of CDH1 Function - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9768203] Multifactorial regulation of E-cadherin expression: an integrative study [LiteratureReference:9768734] Regulation of cadherin adhesive activity [LiteratureReference:9935148] The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC [LiteratureReference:9934434] Dynamics and functions of E-cadherin complexes in epithelial cell and tissue morphogenesis [LiteratureReference:9935586] Loss of E-Cadherin-Dependent Cell-Cell Adhesion and the Development and Progression of Cancer [LiteratureReference:9935133] Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin [LiteratureReference:9935589] The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges [LiteratureReference:9766452] Regulatory Variants and Disease: The E-Cadherin -160C/A SNP as an Example
maxDepth	4
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Regulation of CDH1 Expression and Function
orthologousEvent	[Pathway:R-DRE-9764265] Regulation of CDH1 Expression and Function - Danio rerio [Pathway:R-GGA-9764265] Regulation of CDH1 Expression and Function - Gallus gallus [Pathway:R-XTR-9764265] Regulation of CDH1 Expression and Function - Xenopus tropicalis [Pathway:R-CEL-9764265] Regulation of CDH1 Expression and Function - Caenorhabditis elegans [Pathway:R-DME-9764265] Regulation of CDH1 Expression and Function - Drosophila melanogaster [Pathway:R-BTA-9764265] Regulation of CDH1 Expression and Function - Bos taurus [Pathway:R-CFA-9764265] Regulation of CDH1 Expression and Function - Canis familiaris [Pathway:R-RNO-9764265] Regulation of CDH1 Expression and Function - Rattus norvegicus [Pathway:R-MMU-9764265] Regulation of CDH1 Expression and Function - Mus musculus [Pathway:R-SSC-9764265] Regulation of CDH1 Expression and Function - Sus scrofa
releaseDate	2025-06-18
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9764265
summation	[Summation:9768745] CDH1 (also known as E-cadherin, epithelial cadherin, Cadh...

Referrals

(hasEvent)	[Pathway:R-HSA-9764274] Regulation of Expression and Function of Type I Classical Cadherins
(hasEncapsulatedEvent)	[Pathway:R-HSA-9958825] Activation of STAT3 by cadherin engagement

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