IKBKB-induced proteolysis of NFkB p105 to p50 releases MAP3K8 (TPL2) from the complex with NFkB p105 and ABIN2. On TLR or IL1beta stimulation, dissociated MAP3K8 with an adequate phosphorylation state activates MAP2K (MKK1/2) and consequently MAPK1/3 (ERK1/2).
Waterfield, MR, Zhang, M, Norman, LP, Sun, SC
Beinke, S, Deka, J, Lang, V, Belich, MP, Walker, PA, Howell, S, Smerdon, SJ, Gamblin, SJ, Ley, SC
Roget, K, Ben-Addi, A, Mambole-Dema, A, Gantke, T, Yang, HT, Janzen, J, Morrice, N, Abbott, DW, Ley, SC
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