Reactome | 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105

3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105

Stable Identifier

R-HSA-5684273

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

cytosol

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3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105

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IKBKB-induced proteolysis of NFkB p105 to p50 releases MAP3K8 (TPL2) from the complex with NFkB p105 and ABIN2. On TLR or IL1beta stimulation, dissociated MAP3K8 with an adequate phosphorylation state activates MAP2K (MKK1/2) and consequently MAPK1/3 (ERK1/2).

Literature References

PubMed ID	Title	Journal	Year
12832462	NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity Belich, MP, Ley, SC, Gamblin, SJ, Beinke, S, Smerdon, SJ, Walker, PA, Lang, V, Deka, J, Howell, S	Mol Cell Biol	2003
12667451	NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase Waterfield, MR, Norman, LP, Zhang, M, Sun, SC	Mol Cell	2003
22988300	I?B kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400 Ley, SC, Mambole-Dema, A, Ben-Addi, A, Morrice, N, Roget, K, Abbott, DW, Janzen, J, Yang, HT, Gantke, T	Mol. Cell. Biol.	2012