Reactome | POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template

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POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template Show undefined attributes

authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5655860] Orlic-Milacic, Marija, 2014-12-09
dbId	5655835
deleted	[Deleted:5676179] Deletion of instance: 110321
displayName	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
eventOf	[Pathway:R-HSA-5655862] Translesion synthesis by POLK - Homo sapiens
followingEvent	[Reaction:R-HSA-5655892] POLK incorporates dNMP opposite to damaged DNA base - Homo sapiens
input	[Complex:R-HSA-5655850] MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] [Complex:R-HSA-5655492] POLK:Mg2+,Mn2+ [nucleoplasm] [Complex:R-HSA-110279] POLZ [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3006726] REV1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5655844] Identification of a novel REV1-interacting motif necessary for DNA polymerase kappa function [LiteratureReference:5655838] Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ?, and Pol ? [LiteratureReference:5652156] Structural insights into the assembly of human translesion polymerase complexes [LiteratureReference:5655847] Multifaceted recognition of vertebrate Rev1 by translesion polymerases ? and ? [LiteratureReference:5655488] Bypass of N�-ethylguanine by human DNA polymerase ? [LiteratureReference:5655830] Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA [LiteratureReference:5655970] Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template
orthologousEvent	[Reaction:R-SPO-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Schizosaccharomyces pombe [Reaction:R-GGA-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Gallus gallus [Reaction:R-SSC-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Sus scrofa [Reaction:R-CFA-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Canis familiaris [Reaction:R-RNO-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Rattus norvegicus [Reaction:R-MMU-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Mus musculus
output	[Complex:R-HSA-5655852] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5655835
summation	[Summation:5655856] DNA polymerase kappa (POLK) forms a quaternary complex with ...

Referrals

(replacementInstances)	[Deleted:5676179] Deletion of instance: 110321
(hasEvent)	[Pathway:R-HSA-5655862] Translesion synthesis by POLK
(precedingEvent)	[Reaction:R-HSA-5655892] POLK incorporates dNMP opposite to damaged DNA base