Reactome | POLK incorporates dNMP opposite to damaged DNA base

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POLK incorporates dNMP opposite to damaged DNA base Show undefined attributes

authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
catalystActivity	[CatalystActivity:5655907] DNA-directed DNA polymerase activity of POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5655914] Orlic-Milacic, Marija, 2014-12-09
dbId	5655892
displayName	POLK incorporates dNMP opposite to damaged DNA base
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
eventOf	[Pathway:R-HSA-5655862] Translesion synthesis by POLK - Homo sapiens
followingEvent	[Reaction:R-HSA-5655965] POLK and POLZ cooperate in elongation of mispaired primer termini - Homo sapiens
input	[SimpleEntity:R-ALL-30555] dNTP [nucleoplasm] [Complex:R-HSA-5655852] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5655901] Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides [LiteratureReference:5655880] A role for DNA polymerase ? in promoting replication through oxidative DNA lesion, thymine glycol, in human cells [LiteratureReference:5655893] Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases kappa and zeta in human cells [LiteratureReference:5655887] Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion [LiteratureReference:5655883] Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro [LiteratureReference:5655894] Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa [LiteratureReference:5655878] Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase ? elucidates error-free bypass of a bulky DNA lesion [LiteratureReference:5655868] Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases [LiteratureReference:5655910] Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa [LiteratureReference:5655913] Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions [LiteratureReference:5656288] Detection of smoking-related covalent DNA adducts in human placenta
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	POLK incorporates dNMP opposite to damaged DNA base
orthologousEvent	[Reaction:R-PFA-5655892] POLK incorporates dNMP opposite to damaged DNA base - Plasmodium falciparum [Reaction:R-SPO-5655892] POLK incorporates dNMP opposite to damaged DNA base - Schizosaccharomyces pombe [Reaction:R-CEL-5655892] POLK incorporates dNMP opposite to damaged DNA base - Caenorhabditis elegans [Reaction:R-DME-5655892] POLK incorporates dNMP opposite to damaged DNA base - Drosophila melanogaster [Reaction:R-GGA-5655892] POLK incorporates dNMP opposite to damaged DNA base - Gallus gallus [Reaction:R-DRE-5655892] POLK incorporates dNMP opposite to damaged DNA base - Danio rerio [Reaction:R-SSC-5655892] POLK incorporates dNMP opposite to damaged DNA base - Sus scrofa [Reaction:R-BTA-5655892] POLK incorporates dNMP opposite to damaged DNA base - Bos taurus [Reaction:R-CFA-5655892] POLK incorporates dNMP opposite to damaged DNA base - Canis familiaris [Reaction:R-RNO-5655892] POLK incorporates dNMP opposite to damaged DNA base - Rattus norvegicus [Reaction:R-MMU-5655892] POLK incorporates dNMP opposite to damaged DNA base - Mus musculus
output	[Complex:R-HSA-5655912] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5655892
summation	[Summation:5655866] DNA polymerase kappa (POLK) is the most efficient in incorpo...

Referrals

(precedingEvent)	[Reaction:R-HSA-5655965] POLK and POLZ cooperate in elongation of mispaired primer termini
(hasEvent)	[Pathway:R-HSA-5655862] Translesion synthesis by POLK

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