Reactome | RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA

Schema > Reaction > Entries

RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA Show undefined attributes

authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
catalystActivity	[CatalystActivity:5652007] ubiquitin-protein transferase activity of RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643528] ubiquitin-protein transferase activity of RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5652010] Orlic-Milacic, Marija, 2014-11-26
dbId	5652009
displayName	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
eventOf	[Pathway:R-HSA-110314] Recognition of DNA damage by PCNA-containing replication complex - Homo sapiens
followingEvent	[Reaction:R-HSA-5655481] USP1:WDR48 binds monoUb:K164-PCNA - Homo sapiens [Reaction:R-HSA-5656105] POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA - Homo sapiens [Reaction:R-HSA-110307] REV1 binds AP-dsDNA - Homo sapiens [Reaction:R-HSA-110316] POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template - Homo sapiens [Reaction:R-HSA-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Homo sapiens
input	[Complex:R-HSA-5651985] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5651998] RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO [LiteratureReference:5653648] Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis [LiteratureReference:5653644] Trading places: how do DNA polymerases switch during translesion DNA synthesis? [LiteratureReference:5655179] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass [LiteratureReference:5655463] CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
orthologousEvent	[Reaction:R-CEL-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Caenorhabditis elegans [Reaction:R-DME-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Drosophila melanogaster [Reaction:R-GGA-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Gallus gallus [Reaction:R-DRE-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Danio rerio [Reaction:R-SSC-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Sus scrofa [Reaction:R-BTA-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Bos taurus [Reaction:R-CFA-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Canis familiaris [Reaction:R-RNO-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Rattus norvegicus [Reaction:R-MMU-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Mus musculus
output	[Complex:R-HSA-5652003] MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] [CandidateSet:R-HSA-5651800] POLD,POLE [nucleoplasm] [DefinedSet:R-HSA-5655459] RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5652005] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5652009
summation	[Summation:5652008] The complex of RAD18, an E3 ubiquitin ligase, and UBE2B (RAD...

Referrals

(hasEvent)	[Pathway:R-HSA-110314] Recognition of DNA damage by PCNA-containing replication complex
(precedingEvent)	[Reaction:R-HSA-5655481] USP1:WDR48 binds monoUb:K164-PCNA [Reaction:R-HSA-5656105] POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA [Reaction:R-HSA-110307] REV1 binds AP-dsDNA [Reaction:R-HSA-110316] POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template [Reaction:R-HSA-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template

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