Reactome | Translesion synthesis by POLK

Schema > Pathway > Entries

Translesion synthesis by POLK Show undefined attributes

authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5655863] Orlic-Milacic, Marija, 2014-12-09
crossReference	[DatabaseIdentifier:12325414] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12325416] BioModels Database:BIOMD0000000220
dbId	5655862
displayName	Translesion synthesis by POLK
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
eventOf	[Pathway:R-HSA-110313] Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:10327] error-prone translesion synthesis
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Homo sapiens [Reaction:R-HSA-5655892] POLK incorporates dNMP opposite to damaged DNA base - Homo sapiens [Reaction:R-HSA-5655965] POLK and POLZ cooperate in elongation of mispaired primer termini - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5655844] Identification of a novel REV1-interacting motif necessary for DNA polymerase kappa function [LiteratureReference:5655830] Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA [LiteratureReference:5655901] Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides [LiteratureReference:5655880] A role for DNA polymerase ? in promoting replication through oxidative DNA lesion, thymine glycol, in human cells [LiteratureReference:5655893] Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases kappa and zeta in human cells [LiteratureReference:5655883] Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro [LiteratureReference:5655887] Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion [LiteratureReference:5655894] Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa [LiteratureReference:5655878] Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase ? elucidates error-free bypass of a bulky DNA lesion [LiteratureReference:5655868] Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases [LiteratureReference:5655973] Role of human DNA polymerase kappa as an extender in translesion synthesis [LiteratureReference:5655978] Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Translesion synthesis by POLK Translesion Synthesis by DNA Polymerase Kappa
orthologousEvent	[Pathway:R-PFA-5655862] Translesion synthesis by POLK - Plasmodium falciparum [Pathway:R-SCE-5655862] Translesion synthesis by POLK - Saccharomyces cerevisiae [Pathway:R-SPO-5655862] Translesion synthesis by POLK - Schizosaccharomyces pombe [Pathway:R-DDI-5655862] Translesion synthesis by POLK - Dictyostelium discoideum [Pathway:R-CEL-5655862] Translesion synthesis by POLK - Caenorhabditis elegans [Pathway:R-DME-5655862] Translesion synthesis by POLK - Drosophila melanogaster [Pathway:R-GGA-5655862] Translesion synthesis by POLK - Gallus gallus [Pathway:R-XTR-5655862] Translesion synthesis by POLK - Xenopus tropicalis [Pathway:R-SSC-5655862] Translesion synthesis by POLK - Sus scrofa [Pathway:R-BTA-5655862] Translesion synthesis by POLK - Bos taurus [Pathway:R-CFA-5655862] Translesion synthesis by POLK - Canis familiaris [Pathway:R-RNO-5655862] Translesion synthesis by POLK - Rattus norvegicus [Pathway:R-MMU-5655862] Translesion synthesis by POLK - Mus musculus
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5655862
summation	[Summation:5656198] DNA polymerase kappa (POLK) is a Y family DNA polymerase tha...

Referrals

(hasEvent)

[Pathway:R-HSA-110313] Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Cite Us!