Reactome | POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template

Schema > Reaction > Entries

POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10058393
displayName	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template
eventOf	[Pathway:R-MMU-5655862] Translesion synthesis by POLK - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5655892] POLK incorporates dNMP opposite to damaged DNA base - Mus musculus
inferredFrom	[Reaction:R-HSA-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Homo sapiens
input	[Complex:R-MMU-5655850] MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] [Complex:R-MMU-5655492] POLK:Mg2+,Mn2+ [nucleoplasm] [Complex:R-MMU-110279] POLZ [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-3006726] REV1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template
output	[Complex:R-MMU-5655852] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm]
precedingEvent	[Reaction:R-MMU-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5655835
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5655862] Translesion synthesis by POLK
(precedingEvent)	[Reaction:R-MMU-5655892] POLK incorporates dNMP opposite to damaged DNA base
(inferredTo)	[Reaction:R-HSA-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template

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