Reactome | Signaling by FGFR4 in disease

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Signaling by FGFR4 in disease Show undefined attributes

authored	[InstanceEdit:5649623] Rothfels, Karen, 2014-11-20
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	5655291
deleted	[Deleted:6789864] Deletion of instance: 5655324
disease	[Disease:1500689] cancer
displayName	Signaling by FGFR4 in disease
eventOf	[Pathway:R-HSA-1226099] Signaling by FGFR in disease - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-1839128] FGFR4 mutant receptor activation - Homo sapiens [Reaction:R-HSA-5655351] Activated FGFR4 mutants bind FRS2 - Homo sapiens [Reaction:R-HSA-5655284] Activated FGFR4 mutants phosphorylate FRS2 - Homo sapiens [Reaction:R-HSA-5655348] Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens [Reaction:R-HSA-5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5655252] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5655248] Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens [Reaction:R-HSA-5655235] Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-5655313] Activated FGFR4 mutants bind PLCG1 - Homo sapiens [Reaction:R-HSA-5655341] Activated FGFR4 mutants phosphorylate PLCG1 - Homo sapiens [Reaction:R-HSA-5655336] p-4Y-PLCG1 dissociates from activated FGFR4 mutants - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2021-12-08
literatureReference	[LiteratureReference:2038923] Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models [LiteratureReference:1614268] Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines [LiteratureReference:2011956] The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells [LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes [LiteratureReference:2045073] Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1) [LiteratureReference:1637849] Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma [LiteratureReference:2033248] Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3 [LiteratureReference:2045059] Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele [LiteratureReference:2045062] FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer [LiteratureReference:2045074] The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression
maxDepth	3
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Signaling by FGFR4 in disease
normalPathway	[Pathway:R-HSA-5654743] Signaling by FGFR4
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5655291
summation	[Summation:2045083] FGFR4 is perhaps the least well studied of the FGF receptors...
updateTrackers	[UpdateTracker:9784612] Update Tracker - [Pathway:5655291] Signaling by FGFR4 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway] [UpdateTracker:9775360] Update Tracker - [Pathway:5655291] Signaling by FGFR4 in disease - v79:[updateContainedRLE]

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(updatedInstance)	[UpdateTracker:9784612] Update Tracker - [Pathway:5655291] Signaling by FGFR4 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway] [UpdateTracker:9775360] Update Tracker - [Pathway:5655291] Signaling by FGFR4 in disease - v79:[updateContainedRLE]
(replacementInstances)	[Deleted:6789864] Deletion of instance: 5655324
(hasEvent)	[Pathway:R-HSA-1226099] Signaling by FGFR in disease

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