Reactome | FGFR4 mutant receptor activation

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FGFR4 mutant receptor activation Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1839127] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1839128
disease	[Disease:1500689] cancer
displayName	FGFR4 mutant receptor activation
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
eventOf	[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2012086] Constitutive dimerization of FGFR4 Y367C mutant - Homo sapiens [Reaction:R-HSA-2012087] Autocatalytic phosphorylation of FGFR4 Y367C mutant - Homo sapiens [Reaction:R-HSA-2038946] Dimerization of FGFR4 mutants with enhanced kinase activity - Homo sapiens [Reaction:R-HSA-2038944] Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity - Homo sapiens [Reaction:R-HSA-2046363] FGFR4 kinase mutants are inhibited by PD170734 - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2015-07-02
literatureReference	[LiteratureReference:2011956] The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells [LiteratureReference:2038923] Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models [LiteratureReference:1614268] Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	FGFR4 mutant receptor activation
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1839128
summation	[Summation:5691446] FGFR4 is perhaps the least well studied of the FGF receptors...
updateTrackers	[UpdateTracker:9784561] Update Tracker - [Pathway:1839128] FGFR4 mutant receptor activation - v53:[add_removeSummation, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9784561] Update Tracker - [Pathway:1839128] FGFR4 mutant receptor activation - v53:[add_removeSummation, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease