Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
Signaling by FGFR2 in disease
Show undefined attributes
Go to Details
authored
[InstanceEdit:5649584] Rothfels, Karen, 2014-11-20
created
[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
crossReference
[DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883
dbId
5655253
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
Signaling by FGFR2 in disease
edited
[InstanceEdit:5655392] Rothfels, Karen, 2014-12-05
eventOf
[Pathway:R-HSA-1226099] Signaling by FGFR in disease - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-1839126] FGFR2 mutant receptor activation - Homo sapiens
[Reaction:R-HSA-5655339] Activated FGFR2 mutants bind FRS2 - Homo sapiens
[Reaction:R-HSA-5655268] Activated FGFR2 mutants phosphorylate FRS2 - Homo sapiens
[Reaction:R-HSA-5655233] Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens
[Reaction:R-HSA-5655241] Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens
[Reaction:R-HSA-5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
[Reaction:R-HSA-5655245] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
[Reaction:R-HSA-5655323] Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-5655343] Activated FGFR2 mutants bind PLCG1 - Homo sapiens
[Reaction:R-HSA-5655301] Activated FGFR2 mutants phosphorylate PLCG1 - Homo sapiens
[Reaction:R-HSA-5654748] p-4Y-PLCG1 dissociates from activated FGFR2 mutants - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:2045061] FGFR activation in skeletal disorders: too much of a good thing
[LiteratureReference:2045065] Fibroblast growth factor receptors: lessons from the genes
[LiteratureReference:2046359] Syndromic craniosynostosis: from history to hydrogen bonds
[LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer
[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
[LiteratureReference:2033242] Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma
[LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
[LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
Signaling by FGFR2 in disease
normalPathway
[Pathway:R-HSA-5654738] Signaling by FGFR2
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5655253
summation
[Summation:2046357] The FGFR2 gene has been shown to be subject to activating mu...
Referrals
(hasEvent)
[Pathway:R-HSA-1226099] Signaling by FGFR in disease
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text