Reactome | Signaling by FGFR2 in disease

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Signaling by FGFR2 in disease Show undefined attributes

authored	[InstanceEdit:5649584] Rothfels, Karen, 2014-11-20
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
crossReference	[DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12020828] Mondo:0005497
dbId	5655253
deleted	[Deleted:6789865] Deletion of instance: 5655304
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Signaling by FGFR2 in disease
edited	[InstanceEdit:5655392] Rothfels, Karen, 2014-12-05
eventOf	[Pathway:R-HSA-1226099] Signaling by FGFR in disease - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-1839126] FGFR2 mutant receptor activation - Homo sapiens [Reaction:R-HSA-5655339] Activated FGFR2 mutants bind FRS2 - Homo sapiens [Reaction:R-HSA-5655268] Activated FGFR2 mutants phosphorylate FRS2 - Homo sapiens [Reaction:R-HSA-5655233] Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens [Reaction:R-HSA-5655241] Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens [Reaction:R-HSA-5655245] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5655323] Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-5655343] Activated FGFR2 mutants bind PLCG1 - Homo sapiens [Reaction:R-HSA-5655301] Activated FGFR2 mutants phosphorylate PLCG1 - Homo sapiens [Reaction:R-HSA-5654748] p-4Y-PLCG1 dissociates from activated FGFR2 mutants - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2021-12-08
literatureReference	[LiteratureReference:2045061] FGFR activation in skeletal disorders: too much of a good thing [LiteratureReference:2045065] Fibroblast growth factor receptors: lessons from the genes [LiteratureReference:2046359] Syndromic craniosynostosis: from history to hydrogen bonds [LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:2033242] Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma [LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival [LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
maxDepth	4
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Signaling by FGFR2 in disease
normalPathway	[Pathway:R-HSA-5654738] Signaling by FGFR2
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5655253
summation	[Summation:2046357] The FGFR2 gene has been shown to be subject to activating mu...
updateTrackers	[UpdateTracker:9775416] Update Tracker - [Pathway:5655253] Signaling by FGFR2 in disease - v79:[updateContainedRLE] [UpdateTracker:9784567] Update Tracker - [Pathway:5655253] Signaling by FGFR2 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway] [UpdateTracker:9783496] Update Tracker - [Pathway:5655253] Signaling by FGFR2 in disease - v56:[updateContainedPathway]

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(updatedInstance)	[UpdateTracker:9775416] Update Tracker - [Pathway:5655253] Signaling by FGFR2 in disease - v79:[updateContainedRLE] [UpdateTracker:9784567] Update Tracker - [Pathway:5655253] Signaling by FGFR2 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway] [UpdateTracker:9783496] Update Tracker - [Pathway:5655253] Signaling by FGFR2 in disease - v56:[updateContainedPathway]
(replacementInstances)	[Deleted:6789865] Deletion of instance: 5655304
(hasEvent)	[Pathway:R-HSA-1226099] Signaling by FGFR in disease

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