Reactome | p-4Y-PLCG1 dissociates from activated FGFR2 mutants

Schema > Reaction > Entries

p-4Y-PLCG1 dissociates from activated FGFR2 mutants Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	dissociation
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5654746] Rothfels, Karen, 2014-12-03
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	5654748
deleted	[Deleted:5655671] Deletion of instance: 2077385
disease	[Disease:2032940] bone development disease [Disease:1500689] cancer
displayName	p-4Y-PLCG1 dissociates from activated FGFR2 mutants
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654744] gain_of_function of Activated FGFR2 mutants:p-4Y-PLCG1 [plasma membrane]
eventOf	[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease - Homo sapiens
input	[Complex:R-HSA-5654745] Activated FGFR2 mutants:p-4Y-PLCG1 [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:189824] Phospholipase C-gamma as a signal-transducing element
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-4Y-PLCG1 dissociates from activated FGFR2 mutants
normalReaction	[Reaction:R-HSA-5654157] p-4Y-PLCG1 dissociates from activated FGFR2
output	[DefinedSet:R-HSA-5654747] Activated FGFR2 mutants [plasma membrane] [EntityWithAccessionedSequence:R-HSA-167679] p-4Y-PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5655301] Activated FGFR2 mutants phosphorylate PLCG1 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654748
summation	[Summation:191520] Dissociation from the activated receptor quickly follows pho...

Referrals

(replacementInstances)	[Deleted:5655671] Deletion of instance: 2077385
(hasEvent)	[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease

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