Reactome | FGFR2 mutant receptor activation

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FGFR2 mutant receptor activation Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1839125] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	1839126
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	FGFR2 mutant receptor activation
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
eventOf	[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-2033519] Activated point mutants of FGFR2 - Homo sapiens [Pathway:R-HSA-2023837] Signaling by FGFR2 amplification mutants - Homo sapiens [Pathway:R-HSA-8851708] Signaling by FGFR2 IIIa TM - Homo sapiens [Pathway:R-HSA-8853333] Signaling by FGFR2 fusions - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2016-03-24
literatureReference	[LiteratureReference:2045065] Fibroblast growth factor receptors: lessons from the genes [LiteratureReference:2045061] FGFR activation in skeletal disorders: too much of a good thing [LiteratureReference:2046359] Syndromic craniosynostosis: from history to hydrogen bonds [LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes [LiteratureReference:2029807] FGFR2 mutations are rare across histologic subtypes of ovarian cancer [LiteratureReference:1637923] Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers [LiteratureReference:2029799] Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain [LiteratureReference:2029802] Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities [LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation [LiteratureReference:2033243] A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases [LiteratureReference:2023829] Immunohistochemical detection of K-sam protein in stomach cancer [LiteratureReference:2023825] Deletion of the carboxyl-terminal exons of K-sam/FGFR2 by short homology-mediated recombination, generating preferential expression of specific messenger RNAs [LiteratureReference:2023817] Up-regulation and co-expression of fibroblast growth factor receptors in human gastric cancer [LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival [LiteratureReference:2023815] Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets [LiteratureReference:2029804] Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE [LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor [LiteratureReference:2023814] Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform [LiteratureReference:2029811] Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis [LiteratureReference:2023835] Ligand-independent activation of fibroblast growth factor receptor-2 by carboxyl terminal alterations
maxDepth	3
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	FGFR2 mutant receptor activation
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
revised	[InstanceEdit:8851715] Rothfels, Karen, 2016-01-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1839126
summation	[Summation:5691444] Autosomal dominant mutations in FGFR2 are associated with th...
updateTrackers	[UpdateTracker:9784827] Update Tracker - [Pathway:1839126] FGFR2 mutant receptor activation - v53:[add_removeLiteratureReference, add_removeSummation, updateIndirectRLE] [UpdateTracker:9783722] Update Tracker - [Pathway:1839126] FGFR2 mutant receptor activation - v56:[addHasEvent, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784827] Update Tracker - [Pathway:1839126] FGFR2 mutant receptor activation - v53:[add_removeLiteratureReference, add_removeSummation, updateIndirectRLE] [UpdateTracker:9783722] Update Tracker - [Pathway:1839126] FGFR2 mutant receptor activation - v56:[addHasEvent, modifyText]
(hasEvent)	[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease

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