Reactome | Activated FGFR2 mutants phosphorylate PLCG1

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Activated FGFR2 mutants phosphorylate PLCG1 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:5655250] protein tyrosine kinase activity of Activated FGFR2 mutants:PLCG1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
dbId	5655301
disease	[Disease:2032940] bone development disease [Disease:1500689] cancer
displayName	Activated FGFR2 mutants phosphorylate PLCG1
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655246] gain_of_function of Activated FGFR2 mutants:PLCG1 [plasma membrane]
eventOf	[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease - Homo sapiens
followingEvent	[Reaction:R-HSA-5654748] p-4Y-PLCG1 dissociates from activated FGFR2 mutants - Homo sapiens
input	[Complex:R-HSA-5655346] Activated FGFR2 mutants:PLCG1 [plasma membrane] 4 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:189824] Phospholipase C-gamma as a signal-transducing element
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR2 mutants phosphorylate PLCG1
normalReaction	[Reaction:R-HSA-5654147] Activated FGFR2 phosphorylates PLCG1
output	[Complex:R-HSA-5654745] Activated FGFR2 mutants:p-4Y-PLCG1 [plasma membrane] 4 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5655301
summation	[Summation:2077386] By analogy with the wild-type pathway, PLC-gamma is presumed...

Referrals

(precedingEvent)	[Reaction:R-HSA-5654748] p-4Y-PLCG1 dissociates from activated FGFR2 mutants
(hasEvent)	[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease

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