Reactome | Activated FGFR2 mutants phosphorylate FRS2

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Activated FGFR2 mutants phosphorylate FRS2 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:5655265] protein tyrosine kinase activity of Activated FGFR2 mutants:FRS2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	5655268
deleted	[Deleted:5655667] Deletion of instance: 1982077
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Activated FGFR2 mutants phosphorylate FRS2
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655264] gain_of_function of Activated FGFR2 mutants:FRS2 [plasma membrane]
eventOf	[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease - Homo sapiens
followingEvent	[Reaction:R-HSA-5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
input	[Complex:R-HSA-5655257] Activated FGFR2 mutants:FRS2 [plasma membrane] 6 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer [LiteratureReference:2033241] Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor [LiteratureReference:2067711] GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling [LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling [LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR2 mutants phosphorylate FRS2
normalReaction	[Reaction:R-HSA-5654397] Activated FGFR2 phosphorylates FRS2
output	[Complex:R-HSA-5655236] Activated FGFR2 mutants:p-FRS2 [plasma membrane] 6 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5655268
summation	[Summation:1982078] After recruitment to activated FGFR mutants, FRS2 is believe...

Referrals

(replacementInstances)	[Deleted:5655667] Deletion of instance: 1982077
(precedingEvent)	[Reaction:R-HSA-5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
(hasEvent)	[Pathway:R-HSA-5655253] Signaling by FGFR2 in disease