Reactome | p-CBL:GRB2 binds p-FRS2:activated FGFR4

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p-CBL:GRB2 binds p-FRS2:activated FGFR4 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654735] Rothfels, Karen, 2014-12-03
dbId	5654734
deleted	[Deleted:5655529] Deletion of instance: 1270439
displayName	p-CBL:GRB2 binds p-FRS2:activated FGFR4
eventOf	[Pathway:R-HSA-5654733] Negative regulation of FGFR4 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5654684] CBL ubiquitinates FRS2 and FGFR4 - Homo sapiens
input	[Complex:R-HSA-5654330] Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] [Complex:R-HSA-182964] p-Y371-CBL:GRB2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1268080] FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	p-CBL:GRB2 binds p-FRS2:activated FGFR4
orthologousEvent	[Reaction:R-DME-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 - Drosophila melanogaster [Reaction:R-GGA-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 - Gallus gallus [Reaction:R-DRE-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 - Danio rerio [Reaction:R-SSC-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 - Sus scrofa [Reaction:R-BTA-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 - Bos taurus [Reaction:R-CFA-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 - Canis familiaris [Reaction:R-RNO-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 - Rattus norvegicus [Reaction:R-MMU-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 - Mus musculus
output	[Complex:R-HSA-5654335] Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654655] Activated FGFR4 phosphorylates PPTN11 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654734
summation	[Summation:1268284] The ubiquitin ligase CBL exists in a complex with GRB2 and i...

Referrals

(replacementInstances)	[Deleted:5655529] Deletion of instance: 1270439
(precedingEvent)	[Reaction:R-HSA-5654684] CBL ubiquitinates FRS2 and FGFR4
(hasEvent)	[Pathway:R-HSA-5654733] Negative regulation of FGFR4 signaling

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