Tyrosine phosphorylation of PPTN11/SHP2 by FGFR kinase is required for activation of the phosphatase activity of PPTN11 and for downstream signaling. Tyrosine phosphorylated PPTN11 plays a major role in the activation of RAS-MAP kinase pathway, although the precise role is not yet clear.
Tregidgo, C, Suhling, K, Ladbury, JE, Ahmed, Z, Schüller, AC
Ischenko, I, Movilla, N, Agazie, YM, Hayman, MJ
Lim, YP, Low, BC, Ong, SH, Guy, GR
protein tyrosine kinase activity of Activated FGFR4:p-FRS:PTPN11 [plasma membrane]
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