Reactome | Activated FGFR4 phosphorylates PPTN11

Activated FGFR4 phosphorylates PPTN11

Stable Identifier

R-HSA-5654655

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR4 (Homo sapiens)
      - Downstream signaling of activated FGFR4 (Homo sapiens)
        
        FRS-mediated FGFR4 signaling (Homo sapiens)
        
        Activated FGFR4 phosphorylates PPTN11 (Homo sapiens)

General

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Tyrosine phosphorylation of PPTN11/SHP2 by FGFR kinase is required for activation of the phosphatase activity of PPTN11 and for downstream signaling. Tyrosine phosphorylated PPTN11 plays a major role in the activation of RAS-MAP kinase pathway, although the precise role is not yet clear.

Literature References

PubMed ID	Title	Journal	Year
18373495	Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling Tregidgo, C, Suhling, K, Ladbury, JE, Ahmed, Z, Schüller, AC	Biochem J	2008
14534538	The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 Ischenko, I, Movilla, N, Agazie, YM, Hayman, MJ	Oncogene	2003
9299490	SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells Lim, YP, Low, BC, Ong, SH, Guy, GR	Biochem Biophys Res Commun	1997