Reactome | Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1

Schema > Reaction > Entries

Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5654668] Rothfels, Karen, 2014-12-03
dbId	5654667
deleted	[Deleted:5655540] Deletion of instance: 190401
displayName	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
eventOf	[Pathway:R-HSA-5654720] PI-3K cascade:FGFR4 - Homo sapiens
followingEvent	[Reaction:R-HSA-5654669] Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA - Homo sapiens
input	[Complex:R-HSA-5654330] Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] [Complex:R-HSA-179864] GRB2:GAB1:PIK3R1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191526] Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. [LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation [LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:1268085] SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
orthologousEvent	[Reaction:R-BTA-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Bos taurus [Reaction:R-DME-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Drosophila melanogaster [Reaction:R-GGA-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Gallus gallus [Reaction:R-XTR-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Xenopus tropicalis [Reaction:R-SSC-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Sus scrofa [Reaction:R-CFA-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Canis familiaris [Reaction:R-RNO-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Rattus norvegicus [Reaction:R-MMU-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Mus musculus
output	[Complex:R-HSA-5654333] Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654655] Activated FGFR4 phosphorylates PPTN11 - Homo sapiens [Reaction:R-HSA-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654667
summation	[Summation:1268184] p-PPTN11 recruits GRB2-GAB1 to the activated receptor.

Referrals

(replacementInstances)	[Deleted:5655540] Deletion of instance: 190401
(hasEvent)	[Pathway:R-HSA-5654720] PI-3K cascade:FGFR4
(precedingEvent)	[Reaction:R-HSA-5654669] Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA