Reactome | Activated FGFR4 phosphorylates PPTN11

Schema > Reaction > Entries

Activated FGFR4 phosphorylates PPTN11 Show undefined attributes

catalystActivity	[CatalystActivity:10181026] protein tyrosine kinase activity of Activated FGFR4:p-FRS:PTPN11 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10181028
displayName	Activated FGFR4 phosphorylates PPTN11
eventOf	[Pathway:R-RNO-5654712] FRS-mediated FGFR4 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 - Rattus norvegicus [Reaction:R-RNO-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5654655] Activated FGFR4 phosphorylates PPTN11 - Homo sapiens
input	[Complex:R-RNO-5654337] Activated FGFR4:p-FRS:PTPN11 [plasma membrane] 2 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated FGFR4 phosphorylates PPTN11
output	[Complex:R-RNO-5654339] Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] 2 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-RNO-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5654655
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5654712] FRS-mediated FGFR4 signaling
(precedingEvent)	[Reaction:R-RNO-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 [Reaction:R-RNO-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
(inferredTo)	[Reaction:R-HSA-5654655] Activated FGFR4 phosphorylates PPTN11