Reactome | Activated FGFR4 phosphorylates FRS2

Schema > Reaction > Entries

Activated FGFR4 phosphorylates FRS2 Show undefined attributes

catalystActivity	[CatalystActivity:10967471] protein tyrosine kinase activity of Activated FGFR4:FRS2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10967475
displayName	Activated FGFR4 phosphorylates FRS2
eventOf	[Pathway:R-CEL-5654712] FRS-mediated FGFR4 signaling - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-5654418] Activated FGFR4 phosphorylates FRS2 - Homo sapiens
input	[Complex:R-CEL-5654182] Activated FGFR4:FRS2 [plasma membrane] 6 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated FGFR4 phosphorylates FRS2
output	[Complex:R-CEL-5654193] Activated FGFR4:p-FRS2 [plasma membrane] 6 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-CEL-5654422] Activated FGFR4 binds FRS2 - Caenorhabditis elegans
regulatedBy	[NegativeRegulation:10967476] Negative regulation by 'Activated FGFR4:p-8T-FRS2 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-5654418
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-5654712] FRS-mediated FGFR4 signaling
(precedingEvent)	[Reaction:R-CEL-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1
(inferredTo)	[Reaction:R-HSA-5654418] Activated FGFR4 phosphorylates FRS2

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