Activated FGFR4 phosphorylates FRS2

Stable Identifier
R-HSA-5654418
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Synonyms
ReviewStatus
5/5
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Activated FGFR4 phosphorylates FRS2
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FRS2 (also known as FRS alpha is activated through tyrosine phosphorylation catalyzed by the protein kinase domain of the activated FGFR. FRS2 contains four binding sites for the adaptor protein GRB2 at residues Y196, Y306, Y349 and Y392, and two binding sites for the protein tyrosine phosphatase PPTN11/SHP2 at residues Y436 and Y471. Different FGFR isoforms may generate different phosphorylation patterns on FRS2 leading to alternate downstream signaling.
Literature References
PubMed ID Title Journal Year
9182757 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Kouhara, H, Hadari, YR, Spivak-Kroizman, T, Schilling, J, Bar-Sagi, D, Lax, I, Schlessinger, J

Cell 1997
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Hadari, YR, Kouhara, H, Lax, I, Schlessinger, J

Mol Cell Biol 1998
8780727 Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2

Ong, SH, Goh, KC, Lim, YP, Low, BC, Klint, P, Claesson-Welsh, L, Cao, X, Tan, YH, Guy, GR

Biochem Biophys Res Commun 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of Activated FGFR4:FRS2 [plasma membrane]

Physical Entity
Activated FGFR4:FRS2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
This event is regulated
Negatively by
Regulator
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Orthologous Events
Activated FGFR4 phosphorylates FRS2 (Bos taurus)
Activated FGFR4 phosphorylates FRS2 (Caenorhabditis elegans)
Activated FGFR4 phosphorylates FRS2 (Canis familiaris)
Activated FGFR4 phosphorylates FRS2 (Danio rerio)
Activated FGFR4 phosphorylates FRS2 (Drosophila melanogaster)
Activated FGFR4 phosphorylates FRS2 (Gallus gallus)
Activated FGFR4 phosphorylates FRS2 (Mus musculus)
Activated FGFR4 phosphorylates FRS2 (Rattus norvegicus)
Activated FGFR4 phosphorylates FRS2 (Sus scrofa)
Activated FGFR4 phosphorylates FRS2 (Xenopus tropicalis)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-07)
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2014-12-04)
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