Reactome | Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1

Schema > Reaction > Entries

Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654660] Rothfels, Karen, 2014-12-03
dbId	5654659
deleted	[Deleted:5655543] Deletion of instance: 1268245
diseaseReaction	[Reaction:R-HSA-5655248] Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
displayName	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
eventOf	[Pathway:R-HSA-5654720] PI-3K cascade:FGFR4 - Homo sapiens
followingEvent	[Reaction:R-HSA-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens
input	[Complex:R-HSA-5654193] Activated FGFR4:p-FRS2 [plasma membrane] [Complex:R-HSA-179864] GRB2:GAB1:PIK3R1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway [LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 [LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
orthologousEvent	[Reaction:R-CFA-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Canis familiaris [Reaction:R-DME-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Drosophila melanogaster [Reaction:R-GGA-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Gallus gallus [Reaction:R-XTR-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Xenopus tropicalis [Reaction:R-SSC-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Sus scrofa [Reaction:R-BTA-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Bos taurus [Reaction:R-RNO-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Rattus norvegicus [Reaction:R-MMU-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Mus musculus
output	[Complex:R-HSA-5654191] Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654418] Activated FGFR4 phosphorylates FRS2 - Homo sapiens [Reaction:R-HSA-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654659
summation	[Summation:1268244] The direct GRB2-binding sites of FRS2 have a major role in a...

Referrals

(replacementInstances)	[Deleted:5655543] Deletion of instance: 1268245
(normalReaction)	[Reaction:R-HSA-5655248] Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
(hasEvent)	[Pathway:R-HSA-5654720] PI-3K cascade:FGFR4
(precedingEvent)	[Reaction:R-HSA-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA