Reactome | Activated FGFR3 binds FRS2

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Activated FGFR3 binds FRS2 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654410] Rothfels, Karen, 2014-12-03
dbId	5654409
deleted	[Deleted:5655573] Deletion of instance: 1268220
diseaseReaction	[Reaction:R-HSA-5655262] Activated FGFR3 point, translocation and fusion mutants bind FRS2 - Homo sapiens
displayName	Activated FGFR3 binds FRS2
eventOf	[Pathway:R-HSA-5654706] FRS-mediated FGFR3 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5654408] Activated FGFR3 phosphorylates FRS2 - Homo sapiens
input	[DefinedSet:R-HSA-5654146] Activated FGFR3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-170963] FRS2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182133] FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors [LiteratureReference:532259] Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins [LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activated FGFR3 binds FRS2
orthologousEvent	[Reaction:R-CEL-5654409] Activated FGFR3 binds FRS2 - Caenorhabditis elegans [Reaction:R-DME-5654409] Activated FGFR3 binds FRS2 - Drosophila melanogaster [Reaction:R-GGA-5654409] Activated FGFR3 binds FRS2 - Gallus gallus [Reaction:R-XTR-5654409] Activated FGFR3 binds FRS2 - Xenopus tropicalis [Reaction:R-DRE-5654409] Activated FGFR3 binds FRS2 - Danio rerio [Reaction:R-BTA-5654409] Activated FGFR3 binds FRS2 - Bos taurus [Reaction:R-CFA-5654409] Activated FGFR3 binds FRS2 - Canis familiaris [Reaction:R-RNO-5654409] Activated FGFR3 binds FRS2 - Rattus norvegicus [Reaction:R-MMU-5654409] Activated FGFR3 binds FRS2 - Mus musculus
output	[Complex:R-HSA-5654180] Activated FGFR3:FRS2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-190385] Autocatalytic phosphorylation of FGFR3b - Homo sapiens [Reaction:R-HSA-190388] Autocatalytic phosphorylation of FGFR3c - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654409
summation	[Summation:1268219] FRS2 (also known as FRS2alpha) is broadly expressed in adult...

Referrals

(replacementInstances)	[Deleted:5655573] Deletion of instance: 1268220
(normalReaction)	[Reaction:R-HSA-5655262] Activated FGFR3 point, translocation and fusion mutants bind FRS2
(hasEvent)	[Pathway:R-HSA-5654706] FRS-mediated FGFR3 signaling
(precedingEvent)	[Reaction:R-HSA-5654408] Activated FGFR3 phosphorylates FRS2