Reactome | Autocatalytic phosphorylation of FGFR3b

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Autocatalytic phosphorylation of FGFR3b Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity	[CatalystActivity:190379] protein tyrosine kinase activity of FGFR3b homodimer bound to FGF [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:190381] de Bono, B, 2007-01-02 14:20:27
dbId	190385
displayName	Autocatalytic phosphorylation of FGFR3b
eventOf	[Pathway:R-HSA-190371] FGFR3b ligand binding and activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5654625] Activated FGFR3 binds SHC1 - Homo sapiens [Reaction:R-HSA-5654224] Activated FGFR3 binds PLCG1 - Homo sapiens [Reaction:R-HSA-5654409] Activated FGFR3 binds FRS2 - Homo sapiens [Reaction:R-HSA-5654623] Activated FGFR3 binds FRS3 - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-190232] FGFR3b homodimer bound to FGF [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:190962] Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation [LiteratureReference:191025] A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 [LiteratureReference:190942] Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction [LiteratureReference:1295588] Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Autocatalytic phosphorylation of FGFR3b
orthologousEvent	[Reaction:R-CEL-190385] Autocatalytic phosphorylation of FGFR3b - Caenorhabditis elegans [Reaction:R-DME-190385] Autocatalytic phosphorylation of FGFR3b - Drosophila melanogaster [Reaction:R-GGA-190385] Autocatalytic phosphorylation of FGFR3b - Gallus gallus [Reaction:R-XTR-190385] Autocatalytic phosphorylation of FGFR3b - Xenopus tropicalis [Reaction:R-DRE-190385] Autocatalytic phosphorylation of FGFR3b - Danio rerio [Reaction:R-BTA-190385] Autocatalytic phosphorylation of FGFR3b - Bos taurus [Reaction:R-CFA-190385] Autocatalytic phosphorylation of FGFR3b - Canis familiaris [Reaction:R-RNO-190385] Autocatalytic phosphorylation of FGFR3b - Rattus norvegicus [Reaction:R-MMU-190385] Autocatalytic phosphorylation of FGFR3b - Mus musculus
output	[Complex:R-HSA-190380] Activated FGFR3b homodimer [plasma membrane] 12 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-190263] FGFR3b binds to FGF - Homo sapiens
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-190385
summation	[Summation:201404] The intrinsic protein tyrosine kinase activity of activated ...
updateTrackers	[UpdateTracker:9792269] Update Tracker - [Reaction:190385] Autocatalytic phosphorylation of FGFR3b - v22:[modifyText] [UpdateTracker:9789603] Update Tracker - [Reaction:190385] Autocatalytic phosphorylation of FGFR3b - v37:[addLiteratureReference, add_removeSummation] [UpdateTracker:9785191] Update Tracker - [Reaction:190385] Autocatalytic phosphorylation of FGFR3b - v52:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9792269] Update Tracker - [Reaction:190385] Autocatalytic phosphorylation of FGFR3b - v22:[modifyText] [UpdateTracker:9789603] Update Tracker - [Reaction:190385] Autocatalytic phosphorylation of FGFR3b - v37:[addLiteratureReference, add_removeSummation] [UpdateTracker:9785191] Update Tracker - [Reaction:190385] Autocatalytic phosphorylation of FGFR3b - v52:[modifyText]
(hasEvent)	[Pathway:R-HSA-190371] FGFR3b ligand binding and activation
(precedingEvent)	[Reaction:R-HSA-5654625] Activated FGFR3 binds SHC1 [Reaction:R-HSA-5654224] Activated FGFR3 binds PLCG1 [Reaction:R-HSA-5654409] Activated FGFR3 binds FRS2 [Reaction:R-HSA-5654623] Activated FGFR3 binds FRS3

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