Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant

Stable Identifier
R-HSA-5637795
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant
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Once recruited, PLC-gamma 1 is assumed to be phosphorylated by EGFRvIII cancer mutant in the same way it is phosphorylated by the wild-type EGFR (Meisenhelder et al. 1989, Wahl et al. 1990).

Literature References
PubMed ID Title Journal Year
2472219 Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

Meisenhelder, J, Rhee, SG, Suh, PG, Hunter, T

Cell 1989
1689311 Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells

Kim, JW, Rhee, SG, Wahl, MI, Kim, H, Nishibe, S, Carpenter, G

J Biol Chem 1990
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of p-5Y-EGFRvIII:PLCG1 [plasma membrane]

Physical Entity
p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
EGFR activates PLC-gamma1 by phosphorylation (Homo sapiens)
Functional status

Gain of function of p-5Y-EGFRvIII:PLCG1 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2014-11-13)
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