Once recruited, PLC-gamma 1 is assumed to be phosphorylated by EGFRvIII cancer mutant in the same way it is phosphorylated by the wild-type EGFR (Meisenhelder et al. 1989, Wahl et al. 1990).
protein tyrosine kinase activity of p-5Y-EGFRvIII:PLCG1 [plasma membrane]
Gain of function of p-5Y-EGFRvIII:PLCG1 [plasma membrane]