Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant

Stable Identifier
R-HSA-5637795
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Once recruited, PLC-gamma 1 is assumed to be phosphorylated by EGFRvIII cancer mutant in the same way it is phosphorylated by the wild-type EGFR (Meisenhelder et al. 1989, Wahl et al. 1990).

Literature References
PubMed ID Title Journal Year
1689311 Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells

Wahl, MI, Nishibe, S, Kim, JW, Kim, H, Rhee, SG, Carpenter, G

J Biol Chem 1990
2472219 Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

Meisenhelder, J, Suh, PG, Rhee, SG, Hunter, T

Cell 1989
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of p-5Y-EGFRvIII:PLCG1 [plasma membrane]

Normal reaction
Functional status

Gain of function of p-5Y-EGFRvIII:PLCG1 [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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