Reactome | EGFR activates PLC-gamma1 by phosphorylation

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EGFR activates PLC-gamma1 by phosphorylation Show undefined attributes

authored	[InstanceEdit:212714] Jassal, Bijay, 2008-02-13
catalystActivity	[CatalystActivity:212705] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:212707] Jassal, Bijay, 2008-02-13
dbId	212710
diseaseReaction	[Reaction:R-HSA-5637795] Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant - Homo sapiens [Reaction:R-HSA-1247844] Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants - Homo sapiens
displayName	EGFR activates PLC-gamma1 by phosphorylation
eventOf	[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma - Homo sapiens
followingEvent	[Reaction:R-HSA-212713] Active PLC-gamma1 dissociates from EGFR - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:212708] Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro [LiteratureReference:212704] Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	EGFR activates PLC-gamma1 by phosphorylation
orthologousEvent	[Reaction:R-CEL-212710] EGFR activates PLC-gamma1 by phosphorylation - Caenorhabditis elegans [Reaction:R-DME-212710] EGFR activates PLC-gamma1 by phosphorylation - Drosophila melanogaster [Reaction:R-GGA-212710] EGFR activates PLC-gamma1 by phosphorylation - Gallus gallus [Reaction:R-XTR-212710] EGFR activates PLC-gamma1 by phosphorylation - Xenopus tropicalis [Reaction:R-DRE-212710] EGFR activates PLC-gamma1 by phosphorylation - Danio rerio [Reaction:R-SSC-212710] EGFR activates PLC-gamma1 by phosphorylation - Sus scrofa [Reaction:R-BTA-212710] EGFR activates PLC-gamma1 by phosphorylation - Bos taurus [Reaction:R-CFA-212710] EGFR activates PLC-gamma1 by phosphorylation - Canis familiaris [Reaction:R-RNO-212710] EGFR activates PLC-gamma1 by phosphorylation - Rattus norvegicus [Reaction:R-MMU-212710] EGFR activates PLC-gamma1 by phosphorylation - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-212710
summation	[Summation:213064] EGFR phosphorylates PLC-gamma1, thus activating it.

Referrals

(normalReaction)	[Reaction:R-HSA-5637795] Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant [Reaction:R-HSA-1247844] Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
(hasEvent)	[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma
(precedingEvent)	[Reaction:R-HSA-212713] Active PLC-gamma1 dissociates from EGFR