Reactome | Hh-Npp binds CDON and PTCH

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Hh-Npp binds CDON and PTCH Show undefined attributes

authored	[InstanceEdit:5627765] Rothfels, Karen, 2014-10-20
category	binding
compartment	[Compartment:261122] ciliary membrane
created	[InstanceEdit:5632651] Rothfels, Karen, 2014-10-28
dbId	5632652
displayName	Hh-Npp binds CDON and PTCH
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
eventOf	[Pathway:R-HSA-5632681] Ligand-receptor interactions - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-197892] CDON [plasma membrane] [CandidateSet:R-HSA-5362783] Hh-Npp [extracellular region] [EntityWithAccessionedSequence:R-HSA-5610415] PTCH1 [ciliary membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5629138] The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice [LiteratureReference:5629141] The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla [LiteratureReference:5628968] All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner [LiteratureReference:5629124] Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors [LiteratureReference:5629120] Interactions between Hedgehog proteins and their binding partners come into view [LiteratureReference:5629110] Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication [LiteratureReference:5629107] Boc is a receptor for sonic hedgehog in the guidance of commissural axons [LiteratureReference:5629135] The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development [LiteratureReference:5629106] Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation [LiteratureReference:5629126] Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Hh-Npp binds CDON and PTCH
orthologousEvent	[Reaction:R-DME-5632652] Hh-Npp binds CDON and PTCH - Drosophila melanogaster [Reaction:R-GGA-5632652] Hh-Npp binds CDON and PTCH - Gallus gallus [Reaction:R-XTR-5632652] Hh-Npp binds CDON and PTCH - Xenopus tropicalis [Reaction:R-SSC-5632652] Hh-Npp binds CDON and PTCH - Sus scrofa [Reaction:R-BTA-5632652] Hh-Npp binds CDON and PTCH - Bos taurus [Reaction:R-CFA-5632652] Hh-Npp binds CDON and PTCH - Canis familiaris [Reaction:R-RNO-5632652] Hh-Npp binds CDON and PTCH - Rattus norvegicus [Reaction:R-MMU-5632652] Hh-Npp binds CDON and PTCH - Mus musculus
output	[Complex:R-HSA-5632590] Hh-Npp:CDON:PTCH [ciliary membrane]
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5632652
summation	[Summation:5632419] CDON is a transmembrane glycoprotein that binds directly to ...

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[Pathway:R-HSA-5632681] Ligand-receptor interactions

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